News & HighlightsNews
Cells use import machinery to export their goods as well
In the bustling economy of the cell, little bubbles called vesicles serve as container ships, ferrying cargo to and from the port — the cell membrane. Some of these vesicles, called post-Golgi vesicles, export cargo made by the cell’s protein factory. Scientists have long believed that other, si...
Genome-wide map shows precisely where microRNAs do their work
MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with such wide-ranging applications as onions that can’t make you cry and therapeutic potential for new treatments for viral infections,...
Research identifies 3D structure of key nuclear pore building block
The genome of complex organisms is stashed away inside each cell’s nucleus, a little like a sovereign shielded from the threatening world outside. The genome cannot govern from its protective chamber, however, without knowing what’s going on in the realm beyond and having the ability to project ...
Research identifies early childhood conditions that lead to adult health disparities
The origins of many adult diseases can be traced to early negative experiences associated with social class and other markers of disadvantage. Confronting the causes of adversity before and shortly after birth may be a promising way to improve adult health and reduce premature deaths, researchers...
Misreading of histone code linked to human cancer
The development of blood from stem cell to fully formed blood cell follows a genetically determined program. When it works properly, blood formation stops when it reaches maturity. But when it doesn’t, genetic mutations can prevent the stop signal and cause the developing cells to turn cancerous....
Genetic profiling reveals genes active in the earliest brain circuit construction
Long before the brain’s neurons can facilitate life’s big decisions, they have to find their own destiny in the rapidly developing embryo. In the lingo of neurobiologists, they are “fated” very early on to become certain types of cells, over time traveling to and organizing the various struc...
To spread, skin cancer attacks immune dendritic cells
Dendritic cells are the sentinels of the immune system. When they’re alert and on guard, they will marshal the body’s immunosoldiers, T cells, to battle at the sight of harmful pathogens. But some diseases, such as cancer, are able to escape their watchful eye. By knocking out or beguiling dendr...
For different species, different functions for embryonic microRNAs
When evolution has lucked into efficient solutions for life’s most fundamental problems, it adopts them as invaluable family heirlooms, passing them down as one species evolves into another. So it was reasonable to expect that a key regulator of embryonic development — a strand of RNA that sheph...
Scientists develop a tool to study deadly parasite's histone code
n the Japanese art of paper folding, a series of folds can make the same sheet of paper into a ballerina or baby elephant. But try unfolding the baby elephant and making it into a ballerina. It’s like trying to make a neuron from a kidney cell. Epigenetics, it turns out, isn’t much different fro...
New tag could enable more detailed structural studies of mammalian proteins
To say our genes are resourceful is a gross understatement. Through ingenious combinations of a paltry 20 amino acids, the basic building blocks of life, genes engineer all of the tissues and organs that are the marvel of our working bodies. Now scientists are adding to the parsimonious genetic r...
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