News & HighlightsNews
Genes help worms decide where to dine
In the famous song by The Clash, “Should I Stay or Should I Go,” the lyrics wrestle with one of the more complicated decisions people make — whether to end a difficult love affair or try to make it work. We aren’t likely to understand exactly how specific genes affect such momentous choices ...
Analysis of sperm differentiation reveals new mode of proteasome regulation
Early in development, cells undergo a controlled demolition that helps to shape their raw, pliable material into the specialized forms they must have to do their jobs as adults. The process by which this occurs is also crucial later in the cell’s life, to take out potentially dangerous trash that...
Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants
Scientists at Rockefeller University have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, often prescribed for depression...
Polarized microscopy technique shows new details of how proteins are arranged
Whether you’re talking about genes, or neurons, or the workings of a virus, at the most fundamental level, biology is a matter of proteins. So understanding what protein complexes look like and how they operate is the key to figuring out what makes cells tick. By harnessing the unique properties ...
'Big picture' of how interferon-induced genes launch antiviral defenses revealed
When viruses attack, one molecule more than any other fights back. Interferon triggers the activation of more than 350 genes, and despite the obvious connection, the vast majority have never been tested for antiviral properties. A team of researchers, led by scientists from Rockefeller University...
Researchers put potent staph killer to the test, hope for new drug treatment
Standard antibiotics, and even those reserved for the most defiant infections, are fighting an uphill battle against the evolutionary ingenuity of bacterial defenses. Staphylococci, and especially methicillin-resistant Staphylococcus aureus (MRSA), is a particular scourge in hospitals, and is inc...
Bullying alters brain chemistry, leads to anxiety
Being low mouse on the totem pole is tough on murine self-esteem. It turns out it has measurable effects on brain chemistry, too, according to recent experiments at Rockefeller University. Researchers found that mice that were bullied persistently by dominant males grew unusually nervous around n...
University receives accreditation for its human research protection program
The Rockefeller University has received accreditation from The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP), a program that recognizes research organizations’ commitments to providing strong safeguards on behalf of human research participants. Considered ...
Molecule that spurs cell’s recycling center may help Alzheimer’s patients
Cells, which employ a process called autophagy to clean up and reuse protein debris leftover from biological processes, were the original recyclers. A team of scientists from Paul Greengard’s Rockefeller University laboratory have linked a molecule that stimulates autophagy with the reduction of ...
New genetic technique probes the cause of skin cell differentiation in mammals
A tremendous amount of genetics research has been done in flies and tiny worms, in part because scientists have good tools for tweaking these creatures’ DNA. Now, by adapting a powerful method of RNA interference for use in mice, researchers have identified key pathways that cause skin cells to d...
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