News & HighlightsNews
Study details microRNA’s role as a double agent during Hep C infection
In the battle between a cell and a virus, either side may resort to subterfuge. Molecular messages, which control the cellular machinery both sides need, are vulnerable to interception or forgery. New research at Rockefeller University has revealed the unique twist on just such a strategy deploye...
Growth signal can influence cancer cells’ vulnerability to drugs, study suggests
In theory, a tumor is an army of clones, made up of many copies of the original cancerous cell. But tumor cells don’t always act like duplicates, and their unpredictable behavior can create problems for treatment. For while some cells within a tumor succumb to anti-cancer drugs, others may surviv...
Research captures transient details of HIV genome packaging
Once HIV-1 has hijacked a host cell to make copies of its own RNA genome and viral proteins, it must assemble these components into new virus particles. The orchestration of this intricate assembly process falls to a viral protein known as Gag. For one thing, Gag must be able to discern viral RNA...
Virus-cutting enzyme helps bacteria remember a threat
Bacteria may not have brains, but they do have memories, at least when it comes to viruses that attack them. Many bacteria have a molecular immune system which allows these microbes to capture and retain pieces of viral DNA that they have encountered in the past, in order to recognize and destroy...
Key to blocking influenza virus may lie in a cell’s own machinery
Viruses are masters of outsourcing, entrusting their fundamental function – reproduction – to the host cells they infect. But it turns out this highly economical approach also creates vulnerability. Researchers at Rockefeller University and their collaborators have found an unexpected way the...
Drug-resistant bacteria lurk in subway stations, high school students discover
Forget the five-million plus commuters and untold number of rats – many of the living things crowded into the New York City subway system are too small to see. An interest in the more menacing among these microbes led high school student Anya Dunaif, a participant in Rockefeller’s Summer Science...
Latent HIV may lurk in ‘quiet’ immune cells, research suggests
Drugs for HIV have become adept at suppressing infection, but they still can’t eliminate it. That’s because the medication in these pills doesn’t touch the virus’ hidden reserves, which lie dormant within infected white blood cells. Unlock the secrets of this pool of latent virus, scientists...
Research implicates metabolic process of the liver in the spread of colorectal cancer
Colorectal cancer is a cancer on the move: about 50 percent of patients with the disease see their cancer spread, typically to the liver. By identifying genes that become activated in cancer cells that successfully travel — metastasize — to the liver, researchers at Rockefeller have implicated...
Study detailing axonal death pathway may provide drug targets for neurodegenerative diseases
Axons connect neurons with each other to form the neural networks that underpin the vital functions of perception, motility, cognition, and memory. In many neurodegenerative disorders, from traumatic injury or toxic damage to diseases such as Alzheimer’s or Parkinson’s disease, axonal degenerati...
Long-acting drug effectively prevents HIV-like infection in monkeys
A regime of anti-HIV drugs — components of regimens to treat established HIV infection — has the potential to protect against infection in the first place. But real life can interfere; the effectiveness of this prophylactic approach declines if the medications aren’t taken as prescribed. ...
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