News & HighlightsNews
"Sugar-Coating" on Proteins May Safeguard Body Against Further Insult
M.D.-Ph.D. student shows mannose receptor performs clearance role Much like a cadre of emergency workers at the scene of an accident, the body's immune system cells gather at the site of an injury, whether it is a simple cut or an infection. This microscopic crowd largely consists of inflammatory...
Superbug Update: Only a few families of Staphylococci cause most drug-resistant diseases in hospitals worldwide
Targeting what makes these pervasive families unique may lead to new methods to combat them The culprits behind antibiotic-resistant diseases now plaguing hospitals worldwide have been harboring a secret -- one that Rockefeller scientists have recently exposed. It seems these infectious microbes ...
More Studies Shed Light on How Prozac Works
Nobel laureate Paul Greengard, Ph.D., and other Rockefeller University scientists have illuminated, in laboratory mice, new details of the complex chemical interaction in the brain that is generated by Prozac, the widely prescribed drug for depression. Their findings are reported in a pair of pap...
Cells on the Verge of Suicide
Rockefeller Scientist discovers molecular messengers that rescue cells from death A developing cell in the human body sits on the edge of death. Proteins called Grim, Reaper and Hid stand poised, ready to unleash other toxic proteins. Only if a protein messenger from another cell arrives in time ...
Tidying Up Transcription Factors
Researchers reclassify key protein players of the cell Fifty years ago, in the early days of biology, so little was known about the cell that all of the proteins outside of its nucleus were grouped into one big "cytoplasmic soup." Now, as the list of known cellular ingredients continues to expand...
Pioneering Genome Analysis Reveals the Genes Responsible for Pheromonal Communication Among Rodents
Research among the first published analyses of Celera mouse genome database Rockefeller University scientists report that the way mice communicate with each other is far more complex -- and has a more elaborate evolutionary history -- than imagined. The research, published in the February issue o...
Another Transmembrane Protein Structure Solved by Rockefeller Scientists
Chloride Ion Channel Strikingly Different from Potassium Kin "Why did nature come up with such a structural plan?" ask Rockefeller University professor Roderick MacKinnon and colleagues in their Jan. 17 Nature cover article describing the three-dimensional structure of a type of chloride channe...
Malignant Cells Survive-and Replicate-Because Cancer-causing Molecule Jams Normal p53 Cell-suicide Trigger
Rockefeller Researchers Uncover Clue to Improving Cancer Chemotherapy A cancer-causing molecule called WISP-1 may explain why some people with cancer do not benefit from chemotherapy while others with the same form of cancer respond to the treatment, according to researchers at The Rockefeller Un...
Novel Method To Fight Drug-resistant Infections Emerges from Lab - and Nature
Bacteria's natural foe may prove valuable human friend Scientists have turned to nature once again for help in fighting deadly infections. Reporting in the Dec. 7 issue of Science, Rockefeller University researchers show that a natural enzyme derived from tiny viruses that live inside bacteria...
Researchers Uncover Molecular Basis of Second Leading Cause of Mental Retardation
Protein implicated in fragile X syndrome in charge of crucial brain cell events Scientists at last may have determined how mental retardation develops in people with fragile X syndrome, a condition caused by the inherited loss of an essential protein, termed the fragile X mental retardation prote...
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