Fisher Drug Discovery Resource Center
We focus on early-stage drug discovery, enabling our users and collaborators to advance therapeutic innovation. By combining rigorous technical training and guidance with cutting-edge resources, we aim to remove barriers to scholarly medical research, streamline research processes, and support breakthroughs that contribute to the development of novel treatments for disease. Through collaboration, state-of-the-art technologies, and a commitment to scientific excellence, we seek to make foundational progress on curing disease.
We train and support our users and collaborators through hands-on laboratory and computational investigations focused on the early stages of drug discovery, including miniaturized and automated assay development, molecular screening and mechanism-of-action studies. By integrating fundamental medical science with practical experience we equip trainees with the resources needed to identify and analyze molecules that precisely target cellular pathways. Our center emphasizes key early discovery processes—from screening to lead optimization—fostering a deep molecular understanding of the mechanisms of action of drugs.
We provide our users access to a diverse and well-curated collection of 635,000 drug-like compounds and state-of-the-art bioassay technologies. Through the study of drug-target interactions we enable researchers to refine bioassays, identify promising compounds, and understand the mechanism of action of early-stage compounds and biologics.
(RRID:SCR_020985)
The DDRC supports these technologies and discovery paradigms:
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- high throughput screening
- high content screening
- fragment-based screening
- drug re-positioning
- surface plasmon resonance
- isothermal titration calorimetry
- automated liquid handling and dispensing
- LICOR
- microscale thermophoresis (standard and label-free)
- Dynamic Light Scattering
- Fluorescence Resonance Energy Transfer ( time-gated and non-gated)
- Luminescence oxygen channeling
- HPLC-TOF Mass Spectrometry (reverse phase, analytical scale)
- temperature-related fluorescence intensity change
- Circular Dichroism
- Digital PCR
- Cellular Metabolic Analysis
- Scintillation Proximity
- thermal melt analysis
- Fluorescence kinetics microplate imaging
- Spectral shift analysis
- Cheminformatics
- Bioluminescence Resonance Energy Transfer
- Structure-activity Relationships by inventory
Fisher Drug Discovery Resource Center Lecture, June 5, 2024
