Center for Basic and Translational Research on Disorders of the Digestive System

Diseases that affect the digestive system are among the most prevalent health problems in the world today, but little is known about the fundamental causes and basic biology of these disorders. The Center for Basic and Translational Research on Disorders of the Digestive System, launched in 2012, brings together faculty for intensive interdisciplinary collaboration that will pave the way for new treatments for a broad range of health conditions, including hepatitis C; inflammatory bowel disorders such as Crohn’s disease and ulcerative colitis; obesity and metabolic disorders; celiac disease; and many forms of cancer, notably gastrointestinal stromal tumors (GISTs) and colorectal, liver and pancreatic cancer.

Research efforts include interdisciplinary basic research and collaborations among some 20 Rockefeller labs that study biological processes related to the digestive system, including its interactions with resident microorganisms and its interconnectedness with the immune, circulatory and neuroendocrine systems. The center also encourages translational research that integrates basic studies and clinical investigations centered in The Rockefeller University Hospital, with the goal of making major contributions to the medical management of metabolic diseases, cancers, infections and inflammatory disorders.

Barry S. Coller, M.D.
Director