Heads of Laboratories
Winrich Freiwald, Ph.D.
Laboratory of Neural Systems
Our visual perception of the outer world is the creation of active brain processes that structure and select the information provided by the eyes. Dr. Freiwald is interested in the neural processes that form object representations as well as those that allow attention to make those representations available for cognition.
The brain processes sensory information received by the eyes to form our perceptual world of objects within a three-dimensional space. Object representations combine information on attributes such as shape, color and direction of motion. To understand the mechanisms that control these processes, Dr. Freiwald’s lab focuses on face recognition and attention and uses a range of techniques, including functional brain imaging and electrophysiology.
Faces are a special category of objects that are of high social and, therefore, emotive and cognitive relevance. Using functional magnetic resonance imaging (fMRI), Dr. Freiwald codiscovered a specialized neural machinery for face processing located in the temporal and frontal lobes of the brain. By combining fMRI with electrophysiological techniques, he and his colleagues further showed that this machinery is composed of a small network of a fixed number of face selective regions, termed face patches, each dedicated to a different aspect of face processing and all closely connected with each other. Because the system is specialized to process one class of complex forms, and because its computational components are spatially segregated, the face patch system offers a unique opportunity to dissect the neural mechanisms underlying form perception.
Dr. Freiwald’s laboratory aims to understand the inner workings of this system, from the level of individual cells to the interactions of brain areas, in order to answer questions such as: How does face selectivity emerge in a single cell? How is information transformed from one face patch to another? What is the contribution of each face patch to different face recognition abilities like the recognition of a friend or a smile? How do the different face patches interact in different tasks? And how is information extracted from a patch when a perceptual decision is made?
While the face processing system is used as a model system to understand general object recognition mechanisms, the system also allows fundamental computational questions to be addressed, including: Why is visual information processing organized in hierarchies? How do populations of neurons represent features? And how does activity propagate through the cortex? By studying how the face processing system is embedded in the brain, the Freiwald lab aims to connect it to social behaviors and thereby contribute to understanding disturbances of such behaviors in disease.
The Freiwald lab is also interested in how attentional control is exerted, how it interacts dynamically with the environment, and how attention interplays with sensory object representations. Vision is an active process, and attention is the key active ingredient that selects whatever is relevant for a behavioral goal and dismisses what is not. Dr. Freiwald is using fMRI to determine the entire network of areas involved in attention and identify its connections and functional properties. Using a spatial attention and motion discrimination task, the group has identified one network that includes a new cortical area not previously suspected to be involved in attention. Faces, due to their high social importance, give rise to specific attentional deployments, and the Freiwald lab aims to utilize this link to better elucidate general attention mechanisms.
Dr. Freiwald, a native of Oldenburg, Germany, performed his graduate work at the Max Planck Institute for Brain Research in Frankfurt and received his Ph.D. from Tübingen University in 1998. He then joined the Institute for Brain Research at the University of Bremen as a research assistant. Starting in 2001, he worked as a postdoctoral fellow at the Massachusetts Institute of Technology, Massachusetts General Hospital, Harvard Medical School and the Hanse Institute for Advanced Study in Delmenhorst, Germany. He was head of the primate brain imaging group at the Centers for Advanced Imaging and Cognitive Sciences in Bremen from 2004 to 2008 and a visiting associate at the California Institute of Technology in 2009. He joined The Rockefeller University as assistant professor in 2009. Dr. Freiwald was named a Pew Scholar in 2010 and a McKnight Scholar in 2011; he also received an Esther and Joseph Klingenstein Fellowship in 2010, a Sinsheimer Scholarship in 2010 and an Irma T. Hirschl/Monique Weill-Caulier Trusts Research Award in 2009.
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