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Postdoctoral position in Molecular and Cellular Neuroscience

The Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University is seeking a highly motivated and multi-talented postdoctoral associate, preferably a recent Ph.D. graduate in medicinal chemistry, organic chemistry, or chemical biology, to work on Drug Discovery projects related to the neurodegeneration of the Central Nervous System such as Alzheimer’s disease. Candidates must have an extensive knowledge and experience in biological assay development, High-throughput screening (HTS), in addition to synthetic medicinal chemistry and chemical biology, and have published his/her work in reputed journals ideally in the Neuroscience field. Prior knowledge and experience with computational programs to perform in silico screening are highly desirable. Excellent oral and written communication skills in English are required.

The selected candidate will be responsible for developing HTS assays, perform HTS to identify hit small molecule compounds, design, synthesize and examine new analogs of the hit compounds, and perform studies for the target validation. The candidate must be able to independently design and perform all the studies described above, and analyze results and SAR data to improve drug-like properties of the synthesized compounds. Suitable candidates are expected to perform some in vitro studies involving ELISA assay and cell related work, as well as basic mouse work for determining brain permeability and drug efficacies for example.

Interested candidates should submit a cover letter, CV, a summary of Ph.D. and postdoctoral research, list of publications, and contact information for 2-3 references in a PDF file by e-mail to Subhash C. Sinha, PhD, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065. Apply to: ssinha@rockefeller.edu.  The position is available immediately.