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Postdoctoral Position for DNA-Encoded Chemical Library Synthesis

The Rockefeller University seeks a talented and highly motivated postdoctoral synthetic chemist to work on a particularly ambitious and a collaborative project centered on the development of a DNA‑encoded chemical library. This innovative technology was initially conceived by renowned scientists Dr. Richard A. Lerner of the Scripps Research Institute, and Nobel Laureate Dr. Sydney Brenner, and is currently gaining popularity, as large-scale DNA synthesis and DNA sequencing technologies have become more affordable. The main goals will be to 1) increase the library size by several orders of magnitude, while 2) optimizing, developing and creating novel DNA compatible chemistry reactions. The team will work closely with Dr. Paul Greengard, Nobel Laureate, and his laboratory. The ultimate goal will be to probe numerous biological targets discovered in the Greengard laboratory, as well as other Rockefeller laboratories and elsewhere.

Requirements: The candidate must have a PhD in medicinal chemistry, organic chemistry, or chemical biology. He/she must also have an extensive knowledge/experience in synthetic organic and medicinal chemistry, and have published his/her work in reputed journals. Excellent oral and written communication skills in English are required. The candidate must be highly organized and have a genuine interest in drug discovery. Experience with combinatorial chemistry and mass spectrometric analysis is desirable.

Job Description: The postdoctoral synthetic chemist will work under the supervision of Dr. Subhash Sinha, and collaborate with a team of chemists, as well as a team of biologists and molecular biologists supervised by Dr. Marc Flajolet. The position is available immediately for a year, and will be renewed annually based on productivity and availability of funds. Please submit cover letter, CV, summary of Ph.D. and postdoctoral research, list of publications, and contact information for 2-3 references as a PDF file by e-mail to Subhash C. Sinha, PhD, The Rockefeller University, 1230 York Avenue, New York, NY 10065. E-mail: