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Displaying 73 of 2389 articles.

Genetic mutation helps explain why, in rare cases, flu can kill

...Years after her ordeal, which she survived, scientists led by Jean-Laurent Casanova discovered that it could be explained by a rare mutation she carries that prevented her from producing a protein, interferon, that helps fight off the virus. “This is the first example of a common, isolated and l...

Scientists discover gene mutation that causes children to be born without spleen

...Giles lab, headed by Jean-Laurent Casanova, set out to identify the gene responsible for isolated congenital asplenia. He and his colleagues conducted an international search for patients, and identified 38 affected individuals from 23 families in North and South America, Europe and Africa. Bolze a...

Science online: August 2, 2012

  Huibregtse, Laurent Abel, Stéphanie Boisson-Dupuis and Jean-Laurent Casanova

Key to blocking influenza virus may lie in a cell’s own machinery

...Researchers in Senior Attending Physician and Professor Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics combed through a database containing genetic information on patients who had suffered from severe infectious disease to find those with genetic changes that reduced PAI-1. Biopsie...

Mutations in a single gene underlie vulnerability to two unrelated types of infections

...For the last 20 years, Rockefeller’s Jean-Laurent Casanova, professor, head of the St. Giles Laboratory of Human Genetics and Infectious Disease, Howard Hughes Medical Institute investigator, and a senior attending physician at The Rockefeller University Hospital, has sought to identify the geneti...

Charles Rice to receive 2015 Robert Koch Award

...The announcement marks the second consecutive year that a Rockefeller faculty member has received the Robert Koch Award; last year’s award went to Jean-Laurent Casanova for his work on understanding host genes and their products in infectious diseases. In addition, Ralph Steinman won in 1999 for d...

Nature Immunology: December 25, 2011

...Diaz, J Magarian Blander, Claire-Michèle Farber, Guido Silvestri, Charlotte Cunningham-Rundles, Michaela Calvillo, Carlo Dufour, Lucia Dora Notarangelo, Vassilios Lougaris, Alessandro Plebani, Jean-Laurent Casanova, Stephanie C. Ganal, Andreas Diefenbach, Juan Ignacio Aróstegui, Manel Juan, Jordi ...

Milestones

...Elected: Jean-Laurent Casanova and Leslie B. Vosshall, to the National Academy of Sciences. Dr. Casanova is elected a foreign associate and Dr. Vosshall a member. Established by an act of Congress, the academy provides independent, objective advice to the federal government and other organizations o...

Scientists pinpoint source of recurrent yeast infections in autoimmune syndrome

...In 33 patients with the ailment, known as autoimmune polyendocrine syndrome, or APS-1, researchers led by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, found antibodies that attack a class of immune proteins called cytokines. Although several categories of...

Nature Genetics: December 11, 2011

Nature Genetics online: December 11, 2011 Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome Carine Le Goff, Clémentine Mahaut, Avinash Abhyankar, Wilfried Le Goff, Valérie Serre, Alexandra Afenjar, Anne Destrée, Maja di Rocco, Delphine Héron, Sébastien Jacquemon...

Recent Awards and Honors

Distinguished Teaching Award Plaque

Seth A. Darst and Michael P. Rout receive Distinguished Teaching Awards

June 14, 2018

Darst and Rout were honored at the 2018 Convocation luncheon for their dedication to training Rockefeller graduate students. Together, they teach a course in biochemistry and biophysics methods.

Gregory M. Alushin

Gregory M. Alushin honored as a 2018 Pew Scholar

June 14, 2018

Alushin has been named a biomedical science scholar for his investigation of how cells sense and respond to mechanical force.

More awards and honors

Rockefeller in the News

Scientific American

As [A. James] Hudspeth explored the neural mechanisms of hearing over the years, he developed a special appreciation for the intricate anatomy of the inner ear—an appreciation that transcends the laboratory. “I think we as scientists tend to underemphasize the aesthetic aspect of science,” he says.

Science

"'It is mind-blowing' that cells from such evolutionarily distant species can share these developmental instructions, says Ali Brivanlou, a stem cell biologist at The Rockefeller University in New York City and a senior author on the new study. The organizer 'has been conserved evolutionarily over hundreds of millions of years, so not seeing it would have been a surprise,' he says. But, 'There is something really emotional about looking that far back at human origin.'"

NIH Director's Blog

"[Michael] Rout and [Brian] Chait have spent more than 20 years trying to solve the structure of NPCs. Not only are NPCs large and constantly engaged in shuttling molecules in and out, they also represent moving machines."

 

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