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Displaying 74 of 2421 articles.

A new web tool effectively prioritizes disease-causing genes by biological distance

...Giles Laboratory of Human Genetics of Infectious Disease led by Jean-Laurent Casanova. “It wasn’t enough for the system to work, we needed to make it widely accessible, and we have accomplished that, in part, thanks to the efforts of two high school students,” Itan says. The students, Benj...

Genetic mutation helps explain why, in rare cases, flu can kill

...Years after her ordeal, which she survived, scientists led by Jean-Laurent Casanova discovered that it could be explained by a rare mutation she carries that prevented her from producing a protein, interferon, that helps fight off the virus. “This is the first example of a common, isolated and l...

Scientists discover gene mutation that causes children to be born without spleen

...Giles lab, headed by Jean-Laurent Casanova, set out to identify the gene responsible for isolated congenital asplenia. He and his colleagues conducted an international search for patients, and identified 38 affected individuals from 23 families in North and South America, Europe and Africa. Bolze a...

Science online: August 2, 2012

  Huibregtse, Laurent Abel, Stéphanie Boisson-Dupuis and Jean-Laurent Casanova

Key to blocking influenza virus may lie in a cell’s own machinery

...Researchers in Senior Attending Physician and Professor Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics combed through a database containing genetic information on patients who had suffered from severe infectious disease to find those with genetic changes that reduced PAI-1. Biopsie...

Mutations in a single gene underlie vulnerability to two unrelated types of infections

...For the last 20 years, Rockefeller’s Jean-Laurent Casanova, professor, head of the St. Giles Laboratory of Human Genetics and Infectious Disease, Howard Hughes Medical Institute investigator, and a senior attending physician at The Rockefeller University Hospital, has sought to identify the geneti...

Nature Immunology: December 25, 2011

...Diaz, J Magarian Blander, Claire-Michèle Farber, Guido Silvestri, Charlotte Cunningham-Rundles, Michaela Calvillo, Carlo Dufour, Lucia Dora Notarangelo, Vassilios Lougaris, Alessandro Plebani, Jean-Laurent Casanova, Stephanie C. Ganal, Andreas Diefenbach, Juan Ignacio Aróstegui, Manel Juan, Jordi ...

Charles Rice to receive 2015 Robert Koch Award

...The announcement marks the second consecutive year that a Rockefeller faculty member has received the Robert Koch Award; last year’s award went to Jean-Laurent Casanova for his work on understanding host genes and their products in infectious diseases. In addition, Ralph Steinman won in 1999 for d...

Scientists pinpoint source of recurrent yeast infections in autoimmune syndrome

...In 33 patients with the ailment, known as autoimmune polyendocrine syndrome, or APS-1, researchers led by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, found antibodies that attack a class of immune proteins called cytokines. Although several categories of...


...Elected: Jean-Laurent Casanova and Leslie B. Vosshall, to the National Academy of Sciences. Dr. Casanova is elected a foreign associate and Dr. Vosshall a member. Established by an act of Congress, the academy provides independent, objective advice to the federal government and other organizations o...

Recent Awards and Honors

Gabriel Victora named recipient of an NIH Director’s Pioneer Award

Gabriel Victora named recipient of an NIH Director’s Pioneer Award

October 2, 2018

Victora, head of the Laboratory of Lymphocyte Dynamics, received this grant to expand his novel method that makes it possible to monitor physical interactions between cells.

hixin Liu and Jeremy Rock have each received NIH Director’s New Innovator Awards

Shixin Liu and Jeremy Rock have each received NIH Director’s New Innovator Awards

October 2, 2018

Liu, head of the Laboratory of Nanoscale Biophysics and Biochemistry, and Rock, head of the Laboratory of Host-Pathogen Biology, received grants that are part of the NIH’s High-Risk, High-Reward Research Program.

More awards and honors

Rockefeller in the News

Harper's Magazine

Jeffrey Friedman examines how World War I delayed a treatment for diabetes and derailed one man’s chance at immortality.


"Error-free genomes from a broad sampling of vertebrates will enable researchers 'to address questions not possible to [answer] before,' adds neuroscientist Erich Jarvis of The Rockefeller University in New York City, who leads G10K."

New York Times

By looking at which genes are activated in the brains of queens and workers of different ant species, Dr. [Daniel] Kronauer and his colleagues determined that a hormone called insulin-peptide 2, or ILP2, played the most important role.



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