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Displaying 73 of 2389 articles.

Researchers develop gene-filtering tool to identify disease-causing mutations

...A new tool, developed by scientists in Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University aims to predict whether a given human gene is likely to harbor disease-causing mutations. The hope is that their tool, described the Proceedings of...

Michel C. Nussenzweig honored with the 2016 Robert Koch Award

...Jean-Laurent Casanova received the prize in 2014 for his work on understanding host genes and their products in infectious diseases, and Charles Rice won it last year for his groundbreaking work on the hepatitis C virus. In addition, Ralph Steinman won in 1999 for discovering dendritic cells and the...

Science online: April 11, 2013

Pollard, Catherine Gaud, Pierre Frange, Daniel Orbach, Jean-Francois Emile, Jean-Louis Stephan, Ricardo Sorensen, Alessandro Plebani, Lennart Hammarstrom, Mary Ellen Conley, Licia Selleri and Jean-Laurent Casanova

Charles Rice wins Belgium’s highest scientific prize

...Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, won the award in 2011.

Nature Immunology online: October 28, 2012

Nature Immunology online: October 28, 2012 Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency Bertrand Boisson, Emmanuel Laplantine, Carolina Prando, Silvia Giliani, Elisabeth  Israelsson, Zhaohui Xu, Avinash Abhyankar, Laura Israël, Giraldi...

Gene is linked to deadly runaway fungal infection

...Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, and colleagues examined the genomes of 17 people who had deep dermatophytosis but were otherwise healthy — their immune systems were working well and should have been able to fight off infection. The researcher...

Nature Genetics 44: 1255-1259 (10-21-12)

Nature Genetics 44: 1255-1259 De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy Giulia Barcia, Matthew R Fleming, Aline Deligniere, Valeswara-Rao Gazula, Maile  R Brown, Maeva Langouet, Haijun Chen, Jack Kronengold, Avinash Abhyankar, Roberta Cil...

Journal of Experimental Medicine 210: 2739-2753 (11-18-13)

...Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma and Stuart G. Tangye

A new web tool effectively prioritizes disease-causing genes by biological distance

...Giles Laboratory of Human Genetics of Infectious Disease led by Jean-Laurent Casanova. “It wasn’t enough for the system to work, we needed to make it widely accessible, and we have accomplished that, in part, thanks to the efforts of two high school students,” Itan says. The students, Benj...

Developmental Cell 22: 913-926 (May 15, 2012)

Harvey, Jean-Laurent Casanova, Licia Selleri

Recent Awards and Honors

Distinguished Teaching Award Plaque

Seth A. Darst and Michael P. Rout receive Distinguished Teaching Awards

June 14, 2018

Darst and Rout were honored at the 2018 Convocation luncheon for their dedication to training Rockefeller graduate students. Together, they teach a course in biochemistry and biophysics methods.

Gregory M. Alushin

Gregory M. Alushin honored as a 2018 Pew Scholar

June 14, 2018

Alushin has been named a biomedical science scholar for his investigation of how cells sense and respond to mechanical force.

More awards and honors

Rockefeller in the News

Scientific American

As [A. James] Hudspeth explored the neural mechanisms of hearing over the years, he developed a special appreciation for the intricate anatomy of the inner ear—an appreciation that transcends the laboratory. “I think we as scientists tend to underemphasize the aesthetic aspect of science,” he says.

Science

"'It is mind-blowing' that cells from such evolutionarily distant species can share these developmental instructions, says Ali Brivanlou, a stem cell biologist at The Rockefeller University in New York City and a senior author on the new study. The organizer 'has been conserved evolutionarily over hundreds of millions of years, so not seeing it would have been a surprise,' he says. But, 'There is something really emotional about looking that far back at human origin.'"

NIH Director's Blog

"[Michael] Rout and [Brian] Chait have spent more than 20 years trying to solve the structure of NPCs. Not only are NPCs large and constantly engaged in shuttling molecules in and out, they also represent moving machines."

 

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