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Fruit fly sperm

From the tiny testes of flies, new insight into how genes arise

A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences—and a better understanding of how evolution moves forward.

Displaying 76 of 2503 articles.

In the News – NPR – Casanova

...The response to influenza is genetically impaired,' says [Jean-Laurent] Casanova. He's hoping that the study will catch the interest of other pediatricians and lead to more patients offering their genomes for further research."
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In Brief

Researchers find genetic link to tuberculosis

...Now, Rockefeller scientist Jean-Laurent Casanova has identified a genetic condition that makes the immune system susceptible to mycobacterial attack. Last year, Casanova showed that the risk of developing TB is heightened in people who have two copies of a particular variation of the gene coding ...
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In Brief

Genetic mutation identified as culprit in rare infectious disease

...In an article published in eLife, Jean-Laurent Casanova has uncovered the human genetics factors that make these outliers susceptible to infection. His team suspected that Whipple’s is the latest in a growing number of genetic defects that increases people’s vulnerability to specific microbes. T...
Keratinocyte skin cells
Science News

Researchers uncover molecular mechanisms of rare skin disease

...Led by Rockefeller scientist Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, a group of researchers recently elucidated the molecular mechanisms that make people with EV vulnerable to ß-HPVs. In a new study, published in the Journal of Experimental ...
Mycobacterium tuberculosis
Science News

Study identifies genetic mutation responsible for tuberculosis vulnerability

...Hoping to better understand why only some people are prone to TB, Jean-Laurent Casanova worked with clinicians across the world to collect DNA samples from patients with active forms of the disease. By analyzing these samples, the researchers discovered that the risk of developing TB is heightened i...
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In Brief

In brief: Mutation explains why some people are more vulnerable to viral brain infection

...Rockefeller’s Jean-Laurent Casanova has identified mutations in a single gene that may explain what goes wrong in cases of encephalitis of the brain stem, the part of the brain that controls many basic functions including heart rate and breathing. Shen-Ying Zhang, assistant professor of clinical i...
Jeffrey V. Ravetch
Awards and Honors

Jeffrey V. Ravetch to receive 2018 Robert Koch Award

...Rice in 2015 for studies of the hepatitis C virus, Jean-Laurent Casanova in 2014 for work on genetic susceptibility to infectious disease, and Ralph Steinman in 1999 for discovering dendritic cells and their influence on immunity. René Jules Dubos was the first Rockefeller recipient of the prize...

Immunity 39: 676-686 (10-17-13)

Immunity 39: 676-686 An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis Bertrand Boissonsend, Chenhui Wang, Vincent Pedergnana, Ling Wu, Sophie Cypowyj, Michel Rybojad, Aziz Belkadi, Capucine Picard, Laurent Abel, Claire Fieschi, Anne Pue...
Nussenzweig portrait
Awards and Honors

Michel C. Nussenzweig wins 2017 Sanofi-Institut Pasteur Award

...Ravetch in 2012 and Jean-Laurent Casanova in 2014.

The Lancet 379: 2500 (June 30, 2012)

The Lancet 379: 2500 Herpes in STAT1 deficiency Beáta Tóth, Leonóra Méhes, Szilvia Taskó, Zsuzsanna Szalai, Zsolt  Tulassay, Sophie Cypowyj, Jean-Laurent Casanova, Anne Puel and László Maródi
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Recent Awards and Honors

Two Rockefeller Scientists honored with NIH Director’s Awards

October 1, 2019

Brian T. Chait and Erich D. Jarvis received the NIH Director’s Transformative Research Award for high-risk, high-reward research. Read more about the awards here.

Laura Duvall Portrait

Laura Duvall receives Blavatnik Regional Award

September 4, 2019

Duvall, a research associate in the lab of Leslie B. Vosshall, is honored for her investigation of the mechanisms by which neuropeptides modulate mosquito behavior.

More awards and honors

Rockefeller in the News

STAT News

Newly named MacArthur ‘Genius’ and neuroscientist talks creativity in science

Fortuitously, or perhaps by design, creativity has been a guiding principle for Ruta, 45, and her work. Both her parents were visual artists, and Ruta herself grew up as a ballet dancer — and at one point considered it a career path.

The Washington Post

Mitchell Feigenbaum, an Architect of Chaos Theory, Dies at 74

A mathematical constant that is one of the keystones of chaos theory has been named for him: the Feigenbaum constant. It was revealed as part of his discovery of a powerful and detailed mathematical description of precisely how in a wide array of seemingly disparate systems, order breaks down and makes the transition to chaos.

NPR

Scientists Make Model Embryos From Stem Cells To Study Key Steps In Human Development

"I really feel like I'm looking at one of the most mysterious aspect of our own existence," Brivanlou says. Brivanlou, Simunovic and their colleagues hope their creations will lead to fundamental discoveries that could have many implications, including a better understanding of the the origins of many diseases.

Seek Spring 2019

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue looks deep into the brains of small critters and their decision-making processes. Also: how research on rare diseases could benefit us all, and much more.

From this issue

Science, society, right and wrong

With science constantly advancing, ethical boundaries need regular recalibration. It’s a task scientists cannot do alone, says developmental biologist Ali H. Brivanlou; all of society needs to engage.

A meticulous map of the placenta

With the first "cellular atlas" of the early human placenta, scientists now have a new way to explore why some pregnancies fail.

 

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Faculty at The Rockefeller University are authoritative sources on a range of topics across the biomedical sciences. For media inquiries, please contact Katherine Fenz.

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