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Displaying 92 of 2856 articles.
Keratinocyte skin cells
Science News

Researchers uncover molecular mechanisms of rare skin disease

...Led by Rockefeller scientist Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, a group of researchers recently elucidated the molecular mechanisms that make people with EV vulnerable to ß-HPVs. In a new study, published in the Journ...
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In Brief

Genetic mutation identified as culprit in rare infectious disease

...In an article published in eLife, Jean-Laurent Casanova has uncovered the human genetics factors that make these outliers susceptible to infection. His team suspected that Whipple’s is the latest in a growing number of genetic defects that increases people’s vulnerability to spec...
Campus News

Awards, arrivals, and promotions

Congratulations to our latest award winners: Jean-Laurent Casanova has been recognized with the Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award is given by the American Society for Clinical Investigation, an honor s...
Mycobacterium tuberculosis
Science News

Study identifies genetic mutation responsible for tuberculosis vulnerability

...Hoping to better understand why only some people are prone to TB, Jean-Laurent Casanova worked with clinicians across the world to collect DNA samples from patients with active forms of the disease. By analyzing these samples, the researchers discovered that the risk of developin...
Campus News

Rockefeller hosts the first New York City symposium on human genetics

...Spearheaded by Rockefeller professor Jean-Laurent Casanova, who is working closely with physician-scientist Bruce Gelb at Icahn School of Medicine at Mount Sinai and geneticist David Goldstein at Columbia University, the group plans to organize two meetings annually. “The goal is...
Science News

Researchers develop gene-filtering tool to identify disease-causing mutations

...A new tool, developed by scientists in Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University aims to predict whether a given human gene is likely to harbor disease-causing mutations. The hope is that their tool, described ...
Science News

New research explains why a common bacterium can produce severe illness

...Jean-Laurent Casanova, head of St. Giles Laboratory of Human Genetics of Infectious Diseases and Howard Hughes Medical Institute Investigator, led a team of researchers to uncover how two different conditions—a genetic immunodeficiency and delayed acquired immunity—can combine to...
Nussenzweig portrait
Awards and Honors

Michel C. Nussenzweig wins 2017 Sanofi-Institut Pasteur Award

...Ravetch in 2012 and Jean-Laurent Casanova in 2014.
Campus News

Awards, arrivals, and promotions

...Jean-Laurent Casanova has been elected to the National Academy of Medicine, the health and medicine arm of the National Academy of Sciences. In what is considered one of the highest honors in medicine, new members are elected to the academy based on their outstanding professional...
Campus News

Talking Science lecture introduces students to the genetic aspects of infectious diseases

As he opened this year’s Talking Science lecture, geneticist Jean-Laurent Casanova made a stark observation to his teenage audience: “If we had been here 150 years ago, about half of you would already have died.” The primary reason, he told the 350 high school students and 60 teache...
Awards and Honors

Charles Rice wins Belgium’s highest scientific prize

...Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, won the award in 2011.
Awards and Honors

Charles Rice to receive 2015 Robert Koch Award

...The announcement marks the second consecutive year that a Rockefeller faculty member has received the Robert Koch Award; last year’s award went to Jean-Laurent Casanova for his work on understanding host genes and their products in infectious diseases. In addition, Ralph Steinman...
Awards and Honors

Michel C. Nussenzweig honored with the 2016 Robert Koch Award

...Jean-Laurent Casanova received the prize in 2014 for his work on understanding host genes and their products in infectious diseases, and Charles Rice won it last year for his groundbreaking work on the hepatitis C virus. In addition, Ralph Steinman won in 1999 for discovering den...

In the News - NPR - Casanova

...The response to influenza is genetically impaired,' says [Jean-Laurent] Casanova. He's hoping that the study will catch the interest of other pediatricians and lead to more patients offering their genomes for further research."

New England Journal of Medicine 369: 1704-1714 (10-31-13)

Vincent, Luyan Liu, Sophie Cypowyj, Carolina Prando, Mélanie Migaud, Lynda Taibi, Aomar Ammar-Khodja, Omar Boudghene Stambouli, Boumediene Guellil, Frederique Jacobs, Jean-Christophe Goffard, Kinda Schepers, Véronique del Marmol, Lobna Boussofara, Mohamed Denguezli, Molka Larif, Hervé Bachelez, L...

Immunity 39: 676-686 (10-17-13)

Immunity 39: 676-686 An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis Bertrand Boissonsend, Chenhui Wang, Vincent Pedergnana, Ling Wu, Sophie Cypowyj, Michel Rybojad, Aziz Belkadi, Capucine Picard, Laurent Abel, Claire Fieschi, Anne ...
Science News

Genetic mutation helps explain why, in rare cases, flu can kill

...Years after her ordeal, which she survived, scientists led by Jean-Laurent Casanova discovered that it could be explained by a rare mutation she carries that prevented her from producing a protein, interferon, that helps fight off the virus. “This is the first example of a common...
Science News

A new web tool effectively prioritizes disease-causing genes by biological distance

...Giles Laboratory of Human Genetics of Infectious Disease led by Jean-Laurent Casanova. “It wasn’t enough for the system to work, we needed to make it widely accessible, and we have accomplished that, in part, thanks to the efforts of two high school students,” Itan says. The stud...
Science News

Gene is linked to deadly runaway fungal infection

...Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, and colleagues examined the genomes of 17 people who had deep dermatophytosis but were otherwise healthy — their immune systems were working well and should have been able to fight off infecti...

Journal of Experimental Medicine online: July 29, 2013

Tangye and Jean-Laurent Casanova
Science News

Scientists discover gene mutation that causes children to be born without spleen

...Giles lab, headed by Jean-Laurent Casanova, set out to identify the gene responsible for isolated congenital asplenia. He and his colleagues conducted an international search for patients, and identified 38 affected individuals from 23 families in North and South America, Europe ...

Proceedings of the National Academy of Sciences USA online: March 18, 2013

Proceedings of the National Academy of Sciences USA online: March 18, 2013 The human gene connectome as a map of short cuts for morbid allele discovery Yuval Itana, Shen-Ying Zhang, Guillaume Vogt, Avinash Abhyankar, Melina Herman, Patrick Nitschke, Dror Fried, Lluis Quintana-Murci, Laurent Abel ...

Science online: April 11, 2013

Pollard, Catherine Gaud, Pierre Frange, Daniel Orbach, Jean-Francois Emile, Jean-Louis Stephan, Ricardo Sorensen, Alessandro Plebani, Lennart Hammarstrom, Mary Ellen Conley, Licia Selleri and Jean-Laurent Casanova

Journal of Experimental Medicine online: July 29, 2013

Tangye and Jean-Laurent Casanova

Journal of Experimental Medicine 210: 2739-2753 (11-18-13)

...Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma and Stuart G. Tangye

The Journal of Experimental Medicine online: August 7, 2012

White, Laurent Abel, Shen-Ying Zhang and Jean-Laurent Casanova

The Journal of Clinical Investigation online: August 1, 2012

Williams, Jean-Laurent Casanova and Emmanuelle Jouanguy

Nature online: October 28, 2012

...Daley, Laurent Abel, Jean-Laurent Casanova, Lorenz Studer and Luigi D. Notarangelo

Nature Immunology online: October 28, 2012

Nature Immunology online: October 28, 2012 Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency Bertrand Boisson, Emmanuel Laplantine, Carolina Prando, Silvia Giliani, Elisabeth  Israelsson, Zhaohui Xu, Avinash Abhyankar, Laura Israël, Girald...

The Journal of Experimental Medicine 209: 1813-1823 (9-24-12)

The Journal of Experimental Medicine 209: 1813-1823 Macrophages induce differentiation of plasma cells through CXCL10/IP-10 Wei Xu, HyeMee Joo, Sandra Clayton, Melissa Dullaers, Marie-Cecile Herve, Derek  Blankenship, Maria Teresa De La Morena, Robert Balderas, Capucine Picard, Jean-Laurent
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