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Teal-colored scanning electron micrograph image of a dendritic cell
Science News

Homing in on the genetics of severe COVID in children

...The patients are sick not because of the virus,” says Rockefeller geneticist Jean-Laurent Casanova. “They're sick because they excessively respond to the virus.” Inborn errors An enduring mystery of COVID has been its wildly varied impact on individuals, with one person getting a...
Campus News

Eight Rockefeller scientists designated most influential researchers

...The 2022 list includes: Paul Bieniasz Marina Caskey Luciano Marraffini Jean-Laurent Casanova James G. Krueger Michel C. Nussenzweig Jeffrey V. Ravetch Charles M. Rice Clarivate selects influential scientists for its prestigious list by first compiling the most highly cited scient...
Charles M. Rice (left) and Chibuzo Enemchukwu (right)
Campus News

A new institute devoted to research on global infectious disease is funded by a $75 million grant

...The institute will also support COVID research launched by geneticist Jean-Laurent Casanova at the outset of the pandemic. His effort to identify genetic differences that predispose some people to developing severe COVID-19 quickly evolved into a collaboration of extraordinary gl...
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In Brief

Missing immune molecule may explain why some HPV patients sprout giant horn-like growths

...How could one virus provoke such a severe reaction in a select few, but leave most people symptom-free? In a new study published in Cell, Rockefeller’s Jean-Laurent Casanova answers this question by examining the genetics of an otherwise healthy patient who contracted a severe ca...
staphylococcus aureus
Science News

The genetic underpinnings of severe staph infections

...Rockefeller immunologist Jean-Laurent Casanova examined the protein-coding genomes of more than 100 patients who had suffered from unexplained severe staph infections. The common genetic thread linking some of th...
Science News
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In Brief

The common thread in severe COVID-19 

...Two papers from the laboratory of Jean-Laurent Casanova previously demonstrated that at least 10 percent of severe cases can be chalked up to either a genetic condition that cripples IFN production, or misguided antibodies that attack those crucial proteins. Now, two new studies ...
Awards and Honors

Jean-Laurent Casanova receives the 2016 Inserm Grand Prix

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has won the 2016 Inserm Grand Prix for his work on the genetic basis of infectious diseases. The prestigious award, given annually by Inserm—the French National Institute ...
Awards and Honors

Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, is the recipient of the 2016 Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award, given by the American Soc...
Science News
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In Brief

How one patient’s rare mutation helped solve a mycobacterial mystery

...The lab of Jean-Laurent Casanova, which has spent 25 years studying the interplay between human genes and mycobacterial disease, continues to uncover the genetic defects that separate those who develop serious infections from those who remain symptomless after being exposed to my...
Awards and Honors

Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova, who investigates genetic vulnerability to infectious diseases among children, has been elected to the U.S. National Academy of Medicine, the health and medicine arm of the National Academy of Sciences. Casanova is professor and head of the St. Giles Lab...
Awards and Honors

Leslie Vosshall and Jean-Laurent Casanova elected to the National Academy of Sciences

...Vosshall, Robin Chemers Neustein Professor and head of the Laboratory of Neurogenetics and Behavior, has been named a member, and Jean-Laurent Casanova, senior attending physician, professor, and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been ...
Awards and Honors

Jean-Laurent Casanova to receive 2014 Robert Koch Award

Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been awarded the 2014 Robert Koch Award from the Berlin, Germany based Robert Koch Foundation. Casanova shares the prize with Alain Fischer from the Collège de France and Ima...
Awards and Honors

Jean-Laurent Casanova honored with 2014 Sanofi-Institut Pasteur Award

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University, has been named a 2014 Sanofi-Institut Pasteur Award winner for his paradigm-shifting discovery of the role of single-gene mutations in infect...
Awards and Honors

Jean-Laurent Casanova appointed HHMI investigator

Jean-Laurent Casanova, senior attending physician at The Rockefeller University Hospital and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been named one of 27 new investigators with the Howard Hughes Medical Institute (HHMI), the nonprofit medical r...
Kawasaki disease
Science News

Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19

...We may find a genetic clue that could help explain what is driving this severe complication in these children, which can in turn inform their clinical care,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller U...
Awards and Honors

Jean-Laurent Casanova to receive 2012 Milstein Award

Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been named the Seymour and Vivian Milstein Award for Excellence in Interferon and Cytokine Research 2012 laureate. He will receive the prize at the annual meeting of the Internation...
Image from Casanova lab
Science News

Scientists trace severe COVID-19 to faulty genes and autoimmune condition

...These findings provide compelling evidence that the disruption of type I interferon is often the cause of life-threatening COVID-19,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University and a Howard H...
DNA code on screen
Science News

The gene hunt to explain why some young, healthy people die from COVID-19

...Infectious diseases are always an interplay between a pathogen and the host’s immunity,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University. “At least some of these patients may suffer from a genetic...
Human cell infected by CMV
Science News

Patient with unusually severe infection leads scientists to a rare type of immune deficiency

...An unexpected life-threatening infectious disease that is not explained by a compromised immune system often turns out to be a genetic disorder,” says lead investigator Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller...
llamas participating in research
Science News

Llamas immune to coronavirus, what zebrafish are thinking, and other memorable science stories of 2020 

...Shortly thereafter, Jean-Laurent Casanova and colleagues made headlines with two reports revealing that people with the most severe cases of the disease frequently lack interferon I, a cluster of proteins that repel viruses, providing the first molecular explanation for why some ...
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In Brief

Researchers find genetic link to tuberculosis

...Now, Rockefeller scientist Jean-Laurent Casanova has identified a genetic condition that makes the immune system susceptible to mycobacterial attack. Last year, Casanova showed that the risk of developing TB is heightened in people who have two copies of a particular varia...
Awards and Honors

Jean-Laurent Casanova honored with Belgium’s highest scientific prize

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University, has received the 2011 InBev-Baillet Latour Health Prize for his pioneering work on the identification of genes that predispose for human infectio...
human papilloma virus
Science News

Study pinpoints rare genetic change that may boost risk of HPV-related illness

...We’ve cracked the enigma of why the boys developed these warts,” says lead investigator Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases. The findings add to a growing body of evidence that is changing how researchers think about in...
Science News
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In Brief

Genetic mutation identified as culprit in rare infectious disease

...In an article published in eLife, Jean-Laurent Casanova has uncovered the human genetics factors that make these outliers susceptible to infection. His team suspected that Whipple’s is the latest in a growing number of genetic defects that increases people’s vulnerability to spec...
Science News
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In Brief

In brief: Mutation explains why some people are more vulnerable to viral brain infection

...Rockefeller’s Jean-Laurent Casanova has identified mutations in a single gene that may explain what goes wrong in cases of encephalitis of the brain stem, the part of the brain that controls many basic functions including heart rate and breathing. Shen-Ying Zhang, assistant profe...
Keratinocyte skin cells
Science News

Researchers uncover molecular mechanisms of rare skin disease

...Led by Rockefeller scientist Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, a group of researchers recently elucidated the molecular mechanisms that make people with EV vulnerable to ß-HPVs. In a new study, published in the Journ...
Mycobacterium tuberculosis
Science News

Study identifies genetic mutation responsible for tuberculosis vulnerability

...Hoping to better understand why only some people are prone to TB, Jean-Laurent Casanova worked with clinicians across the world to collect DNA samples from patients with active forms of the disease. By analyzing these samples, the researchers discovered that the risk of developin...
Nussenzweig portrait
Awards and Honors

Michel C. Nussenzweig wins 2017 Sanofi-Institut Pasteur Award

...Ravetch in 2012 and Jean-Laurent Casanova in 2014.
Biosafety Level 3
Science News

Rockefeller scientists launch a broad range of studies into novel coronavirus

...Rockefeller’s Jean-Laurent Casanova is the world leader in identifying gene mutations responsible for extreme variations in infectious disease outcomes. This research can identify human genes that are essential for resisting viral infection or whose mutation prevents the virus fr...
Jeffrey V. Ravetch
Awards and Honors

Jeffrey V. Ravetch to receive 2018 Robert Koch Award

...Rice in 2015 for studies of the hepatitis C virus, Jean-Laurent Casanova in 2014 for work on genetic susceptibility to infectious disease, and Ralph Steinman in 1999 for discovering dendritic cells and their influence on immunity. René Jules Dubos was the first Rockefeller recipi...
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