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Displaying 95 of 2909 articles.
Nature Immunology online: October 28, 2012
Nature Immunology online: October 28, 2012 Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency Bertrand Boisson, Emmanuel Laplantine, Carolina Prando, Silvia Giliani, Elisabeth  Israelsson, Zhaohui Xu, Avinash Abhyankar, Laura Israël, Girald...
Nature online: October 28, 2012
...Daley, Laurent Abel, Jean-Laurent Casanova, Lorenz Studer and Luigi D. Notarangelo
The Lancet 379: 2500 (June 30, 2012)
The Lancet 379: 2500 Herpes in STAT1 deficiency Beáta Tóth, Leonóra Méhes, Szilvia Taskó, Zsuzsanna Szalai, Zsolt  Tulassay, Sophie Cypowyj, Jean-Laurent Casanova, Anne Puel and László Maródi
The Journal of Experimental Medicine 209: 1813-1823 (9-24-12)
The Journal of Experimental Medicine 209: 1813-1823 Macrophages induce differentiation of plasma cells through CXCL10/IP-10 Wei Xu, HyeMee Joo, Sandra Clayton, Melissa Dullaers, Marie-Cecile Herve, Derek  Blankenship, Maria Teresa De La Morena, Robert Balderas, Capucine Picard, Jean-Laurent
Science online: August 2, 2012
  Huibregtse, Laurent Abel, Stéphanie Boisson-Dupuis and Jean-Laurent Casanova
Key to blocking influenza virus may lie in a cell’s own machinery
...Researchers in Senior Attending Physician and Professor Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics combed through a database containing genetic information on patients who had suffered from severe infectious disease to find those with genetic changes that redu...
Nature Genetics 44: 1255-1259 (10-21-12)
Nature Genetics 44: 1255-1259 De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy Giulia Barcia, Matthew R Fleming, Aline Deligniere, Valeswara-Rao Gazula, Maile  R Brown, Maeva Langouet, Haijun Chen, Jack Kronengold, Avinash Abhyankar, Roberta C...
Developmental Cell 22: 913-926 (May 15, 2012)
Harvey, Jean-Laurent Casanova, Licia Selleri
Mutations in a single gene underlie vulnerability to two unrelated types of infections
...For the last 20 years, Rockefeller’s Jean-Laurent Casanova, professor, head of the St. Giles Laboratory of Human Genetics and Infectious Disease, Howard Hughes Medical Institute investigator, and a senior attending physician at The Rockefeller University Hospital, has sought to i...
Researchers create map of “shortcuts” between all human genes
...Giles lab, headed by Jean-Laurent Casanova, previously showed that children with HSE have mutations in TLR3 or in genes that are closely functionally related to TLR3. In other words, these genes are located at a short biological distance from TLR3. As a result, novel herpes simpl...
Scientists pinpoint source of recurrent yeast infections in autoimmune syndrome
...In 33 patients with the ailment, known as autoimmune polyendocrine syndrome, or APS-1, researchers led by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, found antibodies that attack a class of immune proteins called cytokines. Although sev...
Nature Immunology: December 25, 2011
...Diaz, J Magarian Blander, Claire-Michèle Farber, Guido Silvestri, Charlotte Cunningham-Rundles, Michaela Calvillo, Carlo Dufour, Lucia Dora Notarangelo, Vassilios Lougaris, Alessandro Plebani, Jean-Laurent Casanova, Stephanie C. Ganal, Andreas Diefenbach, Juan Ignacio Aróstegui, ...
Brain displays an intrinsic mechanism for fighting infection
...The lab, headed by Jean-Laurent Casanova, collaborated with scientists at Harvard Medical School and Memorial Sloan-Kettering Cancer Institute to create induced pluripotent stem cells. Made from the patients’ own tissue, the stem cells were developed into central nervous system c...
Nature Genetics: December 11, 2011
Nature Genetics online: December 11, 2011 Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome Carine Le Goff, Clémentine Mahaut, Avinash Abhyankar, Wilfried Le Goff, Valérie Serre, Alexandra Afenjar, Anne Destrée, Maja di Rocco, Delphine Héron, Sébastien Jacquemon...
Protein proves vital in immune response to bacteria
...But the lab, headed by Senior Attending Physician Jean-Laurent Casanova, tapped into their database of 300 people with what’s known as Mendelian susceptibility to mycobacterial disease, a rare disorder that predisposes individuals to become severely ill from exposure to mycobacte...
Genetic epidemiologist named visiting professor
Laurent Abel, a geneticist interested in infectious diseases, has been appointed a visiting professor and member ofJean-Laurent Casanova’s Laboratory of Human Genetics of Infectious Disease. Though he will continue to be based in France — his existing laboratory is at the Necker Sch...
Genetic epidemiologist named visiting professor
ZACH VEILLEUX Laurent Abel, a geneticist interested in infectious diseases, has been appointed a visiting professor and member of Jean-Laurent Casanova’s Laboratory of Human Genetics of Infectious Disease. Though he will continue to be based in France — his existing laboratory is at...
Milestones
...Jean-Laurent Casanova, a 2014 Sanofi-Institut Pasteur Award, recognizing scientific progress in the life sciences. Dr. Casanova is being honored for his discovery of the role of single-gene mutations in infectious diseases, leading to novel treatments for certain pediatric...
Charles M. Rice awarded Dautrebande Prize
...Jean-Laurent Casanova, senior attending physician at The Rockefeller University Hospital and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases received the award in 2004 while at the Necker Medical School in Paris.
Milestones
...Jean-Laurent Casanova, the Presidential Award from the Clinical Immunology Society. Dr. Casanova researches the genetic basis of pediatric infectious diseases and is head of the St. Giles Laboratory of Human Genetics of Infectious Diseases and a Howard Hughes Medical Insti...
Mutation leads to new and severe form of bacterial disease
...Led by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, the work lends further support not only to the controversial idea that an error in a single gene is enough to dramatically alter an individual’s risk for bacterial disease, but also to ...
Genome Center to operate at Rockefeller in interim
...The NYGC also has begun a project with Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller, to sequence 1,000 exomes as part of his immune disorder research.
Clinical immunologist to join Rockefeller University
THANIA BENIOS In September, pediatrician and immunologist Jean-Laurent Casanova will join the Rockefeller University faculty as professor of medicine and head of the Laboratory of Human Genetics of Infectious Diseases. The appointment of Dr. Casanova, who comes to Rockefeller...
Rockefeller immunologist receives Gates Foundation Grand Challenges grant
...The grant will support an innovative global health research project conducted by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, aimed at developing new treatments for pediatric tuberculosis. Casanova’s project is one of 78 grants an...
Clinical immunologist to join Rockefeller University
Jean-Laurent Casanova, a distinguished pediatrician and immunologist, will join the faculty at The Rockefeller University as professor of medicine and head of the Laboratory of Human Genetics of Infectious Diseases in September 2008. Casanova, who comes from Hospital Necker f...
Structural biologist, focused on cell transport machinery, to join faculty
...Chen and a second new faculty member, Joseph Gleeson, are the first mid-career faculty members to be recruited to the university since Jean-Laurent Casanova moved his lab to Rockefeller in 2008. (Dr. Gleeson, from the University of California, San Diego, is a geneticist intereste...
Milestones
...Conley is a member of Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics of Infectious Diseases. Jeffrey V. Ravetch, the Wolf Prize in Medicine. He shares the prize, which includes a monetary award of $100,000, with two other immunologists, John Kappler and Philippa M...
Milestones
...Elected: Jean-Laurent Casanova and Leslie B. Vosshall, to the National Academy of Sciences. Dr. Casanova is elected a foreign associate and Dr. Vosshall a member. Established by an act of Congress, the academy provides independent, objective advice to the federal governmen...
Cori Bargmann wins 2009 Lounsbery Award
...Past recipients of the Lounsbery Award include Rockefeller University’s Günter Blobel, Jean-Laurent Casanova and Elaine Fuchs. “Cori’s work on neural circuits and behavior has already taught us much about how the biology of the brain influences an animal’s decisions,” says Paul N...
Clinical study to probe genetic link to Salmonella diseases
...The symptoms associated with typhoidal Salmonella are the same regardless of the host’s immunological profile,” says Carolina Prando, a postdoctoral fellow in Jean-Laurent Casanova’s Laboratory of Human Genetics of Infectious Diseases and the co-principal investigator of the stud...
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