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World’s first transgenic ants reveal how colonies respond to an alarm

The findings raise tantalizing possibilities for revealing what hundreds of ant odorant receptors are up to.

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New algorithm cleans microbiome data with unprecedented efficiency

The algorithm, dubbed SCRuB, can distinguish native bacteria and viruses from contaminants—a powerful tool for researchers working with the microbiome.

36 students receive Ph.D.s at Rockefeller’s 65th convocation

With this week’s ceremony, Rockefeller has granted Ph.D.s in bioscience to 1,431 students. In addition, Ingrid Daubechies, Marc W. Kirschner, and Evelyn G. Lipper received honorary doctor of science degrees.

Studying the cleanup crew of the genome to illuminate a rare disease

Agata Smogorzewska investigates the handful of DNA repair mechanisms that attempt to correct problems, errors, and breakdowns.

Lab-grown mini lungs could accelerate the study of respiratory diseases  

The labs of Ali Brivanlou and Charles M. Rice collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem cells.

A new approach to Alzheimer’s is unfolding 

Despite decades of scientific struggle, progress been excruciatingly slow. But the tide is turning.

The shape of things to come 

Thanks to cryo-em, the breakthroughs are coming faster than ever for Jue Chen. She explains the exciting applications for medicine and science.

The clearest snapshot of human genomic diversity ever taken

The human reference genome has always been a remarkable but flawed tool. A new "pangenome" aims to correct its oversights and omissions.

Behind the formation and protection of microtubules

Research shed light on the process by which the γ-Tubulin Ring Complex stabilizes microtubules, which may inform the study of developmental diseases and cancers.

Solving the mystery behind how nutrients enter cells

A new paper describes how choline is transported into the cell, with potentially sweeping implications for the study of rare diseases.

Maybe the virus isn't the problem 

Why do some with COVID end up on ventilators while others get a scratchy throat—and yet others seem to have dodged the virus entirely? Answers are emerging from scientists around the globe.

Researchers reveal an ancient mechanism for wound repair

The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.

Gum disease may lie at the root of some arthritis flare-ups

Damaged gums may release bacteria into the bloodstream that trigger arthritis flare-ups, potentially explaining why people with gum disease don't respond as well to arthritis treatments.

How to end a pandemic in one jab 

Universal vaccines can give years of protection against polio, measles, and smallpox, among other diseases. Pamela Bjorkman believes HIV, influenza, and COVID are next.

New tool to study hepatitis B could open the door to a cure

Just as the Rice lab’s work on HCV exposed that virus’s weaknesses, the hope is that this novel approach could do the same for HBV.

Seeking the origin story of de novo genes

Li Zhao studies the intriguing genes that emerge from previously silent or non-coding stretches of DNA.

Scientists discover brain region linking short-term to long-term memory

The anterior thalamus plays such a key role in memory that boosting it in mice consolidates the animals' trivial experiences into long-term memories.

What you get is not just what you see 

Scientists have built a novel AI system that rewrites the rules for computer vision. It might soon turn neuroscience on its head.

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New technique captures unprecedented view of the active brain

The tech, dubbed MesoLF, captures 10,500 neurons buried at once-inaccessible depths, firing from brain regions many millimeters apart, simultaneously—all with unprecedented resolution.

Pioneering forestry researcher Suzanne Simard to receive the 2023 Lewis Thomas Prize

The author of Finding the Mother Tree: Discovering the Wisdom of the Forest will be presented with Rockefeller’s prestigious science writing award on April 17.

Innovative approach opens the door to COVID nanobody therapies

The relatively simple and low-cost procedure could empower laboratories in low-resource areas to generate nanobodies against SARS-CoV-2, as well as other viruses.

Illuminating the evolution of social parasite ants

The findings offer a new way to understand how some ants become total layabouts.

Emil C. Gotschlich, creator of lifesaving vaccines, has died

A molecular chemist whose work has protected millions of people from bacterial meningitis, Gotschlich passed away on February 14. He was 88.

Homing in on the genetics of severe COVID in children

A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.

The nutrient that cancer cells crave

Starving cancer cells of a key amino acid could potentially render tumors more vulnerable to the body’s natural immune response.

Elaine Fuchs awarded Benjamin Franklin Medal in Life Science

Fuchs receives the honor for illuminating the genetics of skin diseases and the mechanisms that guide skin renewal, yielding insights into aging, inflammation, and cancer.

A unique window into "original antigenic sin"

The body's first blush with a pathogen shapes how it will respond to vaccines. New evidence clarifies how this phenomenon works, mechanistically.

How the body's B cell academy ensures a diverse immune response

A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus.

Remembering a pioneer of chromatin biology

Charles David Allis, a molecular biologist who shaped the field of chromatin biology, died on January 8 at the age of 71.

Why older fathers pass on more genetic mutations to their offspring

It's not just the number of mutations that matters. It's the failure to fix them too.

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Solving a crucial bottleneck in drug discovery

A novel method reduces the time required to identify novel antibiotic-producing DNA from weeks to days.

When the body's B cell training grounds stay open after hours

While most germinal centers shut down after a few weeks, some stay in business for more than six months. A new study helps explain why.

Intriguing science discoveries of 2022

Breakthroughs in genetics, biochemistry, neuroscience, infectious disease, and drug development were a few of the year's highlights.

Markus Library prepares researchers for new NIH data management policy

The library is offering new tools and training to support researchers operating under an updated NIH policy.

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How a cell's mitochondria make their own protein factories

The findings shed a rare light on mitoribosomes, the unique ribosomes found within the cell's mitochondria.

How antibody therapy impacts COVID vaccines

People who receive monoclonal antibodies before vaccines may benefit from increased coverage, due to antibody feedback inhibition.

Research on rare genetic disease sheds light on a common head and neck cancer

Patients with Fanconi anemia have an elevated risk for squamous cell carcinoma, a highly aggressive head-and-neck cancer. New findings pinpoint the mechanisms linking the two conditions, and also shed new light on how smoking or drinking may elevate anyone’s cancer risk.

Cancer stem cells are fueled through dialogue with their environments

The findings suggest that many of the mutations in cancer may simply be setting in stone a path already forged by the tumor stem cell’s aberrant dialogue with its surroundings.

Ant pupae secrete fluid as "milk" to nurture young larvae

This newly discovered “social fluid” appears to unite ant colonies across developmental stages into one superorganism.

A new institute devoted to research on global infectious disease is funded by a $75 million grant

Rockefeller’s new Stavros Niarchos Foundation Institute for Global Infectious Disease Research will provide a framework for international scientific collaboration.

Eight Rockefeller scientists designated most influential researchers

Clarivate, a British analytics company, recognizes individuals "who demonstrate significant and broad influence among their peers in their chosen field or fields of research."

From the piano bench to the lab bench

Gabriel D. Victora is unlocking the mysteries of how the body generates antibodies to defend itself from pathogens. But there was a time when science was not even on his radar.

Promising new drug target for a rare liver cancer

Fibrolamellar carcinoma needs one specific mutation in order to thrive, and impeding it reduces tumor growth in mice.

Fruit flies move their retinas much like humans move their eyes

Insects cannot move their eyes the way humans do during a tennis game. But new research suggests fruit flies evolved a different strategy to adjust their vision without moving their heads.

New evidence of biochemical states and force working in concert

When an actin filament bends during cell movement, older actin deforms differently than newer actin, allowing regulatory proteins to tell the two states apart.

Mathematical modeling suggests counties are still unprepared for COVID spikes

If jurisdictions plan to share resources in advance, the study concludes, this could prevent one rare event from overwhelming a county or state.

Shixin Liu wins 2023 Vilcek Prize for Creative Promise in Biomedical Science

Liu is one of four scientists across the country to receive the prestigious prize, which recognizes scientists who have immigrated to the United States for early-career contributions.

Why some people are mosquito magnets

The female mosquito will hunt down any human, but some of us get bitten far more than others. The answer why may be hidden in our skin.

Sohail Tavazoie elected to the National Academy of Medicine

A trailblazing physician-scientist, Tavazoie has substantially expanded our understanding of the mechanisms enabling some tumors to spread from one body site to another. He is the 18th member of Rockefeller’s faculty elected to the academy.

Albany Medical Center Prize awarded to C. David Allis

Allis receives the honor for discovering new mechanisms regulating gene expression.

The brain cells that slow us down when we're sick

New study pinpoints the cluster of neurons that tell mice to eat, drink, and move around less when they're fighting bacterial infections.  

New workshop brings exceptional scholars to campus

Postdoctoral fellows from diverse backgrounds attended the two-day program, designed to ease their transition to independent investigators.

Common mutation linked to COVID mortality

Because three percent of the world population possesses these gene variants, the findings may have implications for hundreds of millions of individuals around the world.

Josefina del Mármol named Blavatnik Regional Award Winner in life sciences

Del Mármol receives the honor for her research leading to the first-ever molecular images of an olfactory receptor at work.

The tech that money can’t buy 

What if the tool needed to move science forward doesn’t yet exist? Here are gadgets and techniques born from improvisation that made impossible experiments possible.

Tim Stearns becomes new dean of graduate and postgraduate studies

Stearns, who assumes the role on September 1, reflects upon his new job and his vision for the university’s educational programs.

Rockefeller postdocs Begüm Aydin and Alain Bonny named Hanna Gray Fellows

Aydin, of the Mucida lab, and Bonny, a member of the Fuchs lab, received HHMI’s prestigious fellowship for exceptional early career scientists on August 24.

Unlocking the mystery of how mosquitoes smell humans

Through questioning their assumptions about how mosquitoes sense and interpret odors, scientists may have discovered why efforts to throw the vectors of dengue and Zika off the human scent have not succeeded.

Nicola Khuri, theoretical physicist and scientific-community builder, has died

Nicola N. Khuri, a theoretical physicist known for using math to describe and predict what happens when elementary particles collide in giant accelerators, died on August 4 at age 89.

New faculty member unlocks vast chemical spaces for drug discovery

Jiankun Lyu will join Rockefeller as an assistant professor on January 1, 2023.