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Scientists shed light on biological roots of individuality

A new study illuminates the biology that guides behavior across different stages of life in worms, and suggests how variations in specific neuromodulators in the developing nervous system may lead to occasional variations.

In brief: New molecular insights on a rare immune disorder

After figuring out the functions of two proteins involved in the rare genetic condition ICF, scientists pieced together the molecular process that is altered in the disease.

New images reveal how the ear’s sensory hairs take shape

Our ability to hear relies on tiny bundles of hair-like sensors inside the inner ear. Scientists have identified a key component of the machinery that makes these bundles grow in an orderly fashion.

New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.

Uncovering the early origins of Huntington’s disease

The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.

New immunotherapy approach boosts body’s ability to destroy cancer cells

A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.

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In brief: Variation between strains may account for differences in people’s vulnerability to infection

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

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In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.

Proof of principle: Tri-I TDI drug candidates “graduate” to next phase of development

As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to investigational new drugs.

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

Recent Awards and Honors

Junyue Cao

Junyue Cao wins Science & SciLifeLab Grand Prize For Young Scientists

November 19, 2020

Cao is recognized for his work using single-cell genomic methods to enable developmental mapping of entire organisms, described in an essay published in Science.
LLuciano Marraffini portrait

Luciano Marraffini awarded Max Planck-Humboldt Medal

October 14, 2020

Marraffini receives the award for his achievements studying CRISPR-Cas, a bacterial immune mechanism whose discovery led to modern gene-editing tools.
More awards and honors

Rockefeller in the News

Nature News

An innovative approach from Priya Rajasethupathy has been used to link genetics to behavior in mice. The analysis identifies a gene that underpins the role of the brain’s thalamus region in maintaining short-term memory.

NBC News

Research led by Jean-Laurent Casanova shows Covid-19 patients with life-threatening illness have antibodies that disable key immune system proteins called interferons.

Knowable Magazine

Just how sick we get from COVID-19 depends on genetic variations, including ones that sabotage immune molecules called interferons. Jean-Laurent Casanova's work aims to better understand why, which could lead to new treatments for COVID-19 and other scourges.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue takes us inside the response to the pandemic, where scientists are using every tool in the 21st century playbook to transform COVID-19 into a manageable disease. Also: Mosquito menace, The brain inside your gut, and Addiction then and now.


From this issue

 


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