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Study uncovers the molecular events by which popular antidepressants work

Scientists have outlined a molecular program by which serotonin reuptake inhibitors reshape the brain to alleviate depression. Their findings provide clues for how to make better and faster-acting versions of these drugs.

Life's inner mechanics 

Cells—and the molecules inside them—are always on the move. They’re being tugged at, prodded, reshuffled. Behind these actions are tiny forces that, after decades of neglect, are emerging as the next big thing in biology.

Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potentially prevent this.


A never-before-seen image of the coronavirus copy machine

The high-resolution 3D image can speed COVID-19 drug discovery.

How toothless mock viruses could advance research on COVID-19

Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.

Bacteria in the gut have a direct line to the brain

Scientists find that microbes inside the intestines can control the activities of neurons connecting the gut and brain.

Amid the rush for COVID-19 drugs, a case for the helicase

The enzyme is essential for the virus to replicate itself inside our cells. Scientists already have ideas for how to block it.

How neurons in body fat grow to boost calorie-burning capacity

Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue.  Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future.

Becoming a Scientist: Jeanne Garbarino 

Meet Jeanne Garbarino, the scientist whose job it is to get teens out of their textbooks and into the lab.

Novel cells might act as a warning sign for rheumatoid arthritis flares

A genomics study has identified a previously unknown cell type whose blood levels tend to rise and fall in patients with rheumatoid arthritis. The findings could make it easier to manage the disease and help scientists understand its root causes.

Recent Awards and Honors

Amelia Escolano and Marc Schneeberger Pané named Blavatnik Regional Award Finalists

September 23, 2020

Escolano, from Michel C. Nussenzweig’s lab, and Schneeberger Pané, from Jeffrey M. Friedman’s lab, are recognized for their respective postdoctoral work in the life sciences category.

Li Zhao portrait

Li Zhao named a Vallee Scholar

August 12, 2020

Zhao receives the honor for her research on how novel genes arise.

More awards and honors

Rockefeller in the News

The Wall Street Journal

“The immune system in people is as diverse as beauty, height, intelligence and any other human feature,” said molecular immunologist Michel Nussenzweig at Rockefeller University in New York. “Not everybody is the same in their ability to fight infection.”

The Guardian

Clinical use of heritable genome editing should not be considered until it's established that precise genomic changes can be made reliably without introducing undesired changes, according to a joint NAS, NAM, and Royal Society commission co-chaired by Rockefeller president Richard P. Lifton.

The Washington Post

A study from the laboratory of Leslie Vosshall, a Rockefeller University Robin Chemers Neustein professor, shows that by giving mosquitoes the minimal components of the blood meal and adding a special drug, the insects will eat and later stop biting.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue takes a look at how cells and molecules are being stretched, tugged at, prodded—and what we might learn about life by studying the physics of it. Also: How to starve a tumor, and much more.


From this issue

 


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