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New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.

Uncovering the early origins of Huntington’s disease

The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.

New immunotherapy approach boosts body’s ability to destroy cancer cells

A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.

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In brief: Variation between strains may account for differences in people’s vulnerability to infection

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

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In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.

Proof of principle: Tri-I TDI drug candidates “graduate” to next phase of development

As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to investigational new drugs.

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

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In brief: Immune cells surveil intestine to prevent infections

Scientists found that immune cells called intraepithelial lymphocytes act as a surveillance force at the intestine, helping to generate an appropriate immune response to both friendly bacteria and dangerous pathogens.

In brief: New clues about how cells restart stalled replication

Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.

Brain research points the way to new treatments for nicotine addiction

Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.

Recent Awards and Honors

Gabriel Victora named recipient of an NIH Director’s Pioneer Award

Gabriel Victora named recipient of an NIH Director’s Pioneer Award

October 2, 2018

Victora, head of the Laboratory of Lymphocyte Dynamics, received this grant to expand his novel method that makes it possible to monitor physical interactions between cells.

hixin Liu and Jeremy Rock have each received NIH Director’s New Innovator Awards

Shixin Liu and Jeremy Rock have each received NIH Director’s New Innovator Awards

October 2, 2018

Liu, head of the Laboratory of Nanoscale Biophysics and Biochemistry, and Rock, head of the Laboratory of Host-Pathogen Biology, received grants that are part of the NIH’s High-Risk, High-Reward Research Program.

More awards and honors

Rockefeller in the News

Science

"Error-free genomes from a broad sampling of vertebrates will enable researchers 'to address questions not possible to [answer] before,' adds neuroscientist Erich Jarvis of The Rockefeller University in New York City, who leads G10K."

New York Times

By looking at which genes are activated in the brains of queens and workers of different ant species, Dr. [Daniel] Kronauer and his colleagues determined that a hormone called insulin-peptide 2, or ILP2, played the most important role.

Scientific American

As [A. James] Hudspeth explored the neural mechanisms of hearing over the years, he developed a special appreciation for the intricate anatomy of the inner ear—an appreciation that transcends the laboratory. “I think we as scientists tend to underemphasize the aesthetic aspect of science,” he says.

 

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Communications and Public Affairs

The Office of Communications and Public Affairs promotes and disseminates research news and other information about The Rockefeller University.