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New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.

Uncovering the early origins of Huntington’s disease

The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.

New immunotherapy approach boosts body’s ability to destroy cancer cells

A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.

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In brief: Variation between strains may account for differences in people’s vulnerability to infection

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

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In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.

Proof of principle: Tri-I TDI drug candidates “graduate” to next phase of development

As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to investigational new drugs.

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

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In brief: Immune cells surveil intestine to prevent infections

Scientists found that immune cells called intraepithelial lymphocytes act as a surveillance force at the intestine, helping to generate an appropriate immune response to both friendly bacteria and dangerous pathogens.

In brief: New clues about how cells restart stalled replication

Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.

Brain research points the way to new treatments for nicotine addiction

Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.

Recent Awards and Honors

Two Rockefeller Scientists honored with NIH Director’s Awards

October 1, 2019

Brian T. Chait and Erich D. Jarvis received the NIH Director’s Transformative Research Award for high-risk, high-reward research. Read more about the awards here.

Laura Duvall Portrait

Laura Duvall receives Blavatnik Regional Award

September 4, 2019

Duvall, a research associate in the lab of Leslie B. Vosshall, is honored for her investigation of the mechanisms by which neuropeptides modulate mosquito behavior.

More awards and honors

Rockefeller in the News

Scientific American

"What we do know tells us that if you are thin, you should thank your 'lean' genes and refrain from stigmatizing the obese. A broad acceptance of the biologic basis of obesity would not only be fair but would allow us to collectively focus on health." -Jeff Friedman

The New York Times

Conventional antibiotics do not distinguish between good and bad bacteria, eradicating everything indiscriminately and occasionally creating problems for people with weakened immune systems.

“A major benefit of Crispr is that we can program it to kill only specific pathogenic bacteria and leave alone the rest of our healthy microbes,” Dr. Marraffini said.

STAT News

Fortuitously, or perhaps by design, creativity has been a guiding principle for Ruta, 45, and her work. Both her parents were visual artists, and Ruta herself grew up as a ballet dancer — and at one point considered it a career path.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue looks deep into the brains of small critters and their decision-making processes. Also: how research on rare diseases could benefit us all, and much more.


From this issue

 

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