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In brief: New molecular insights on a rare immune disorder

After figuring out the functions of two proteins involved in the rare genetic condition ICF, scientists pieced together the molecular process that is altered in the disease.

New images reveal how the ear’s sensory hairs take shape

Our ability to hear relies on tiny bundles of hair-like sensors inside the inner ear. Scientists have identified a key component of the machinery that makes these bundles grow in an orderly fashion.

New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.

Uncovering the early origins of Huntington’s disease

The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.

New immunotherapy approach boosts body’s ability to destroy cancer cells

A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.

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In brief: Variation between strains may account for differences in people’s vulnerability to infection

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

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In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.

Proof of principle: Tri-I TDI drug candidates “graduate” to next phase of development

As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to investigational new drugs.

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

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In brief: Immune cells surveil intestine to prevent infections

Scientists found that immune cells called intraepithelial lymphocytes act as a surveillance force at the intestine, helping to generate an appropriate immune response to both friendly bacteria and dangerous pathogens.

Recent Awards and Honors

Daniel Mucida Portrait

Daniel Mucida named a Pershing Square Sohn Prize–Mathers Foundation Fellow

May 21, 2019

Mucida receives the award for his exploration of the gut’s specialized immune system and its role in colorectal cancer.

Portrait of Elaine Fuchs

Elaine Fuchs elected as a foreign member of the Royal Society

April 17, 2019

Fuchs is recognized for her groundbreaking study of the molecular mechanisms by which skin stem cells make and repair tissues.

More awards and honors

Rockefeller in the News

The New York Times

Paul Greengard, an American neuroscientist whose quest to understand how brain cells communicate provided new insights into psychological diseases and earned him a Nobel Prize, and who used his entire $400,000 award to create an academic prize in memory of the mother he never knew, died on Saturday in Manhattan. He was 93.

Associated Press

Further study may reveal surprises about what mosquitoes pay attention to, [Leslie] Vosshall said. And that could lead to better lures for mosquito traps, as well as better repellents. Maybe scientists can find something “10,000 times more disgusting” to a mosquito than the old standby, DEET, she said.

Discover Magazine Blogs

Scientists at Rockefeller University claim they’ve pinpointed a protein in the ear that acts as a sort of molecular gatekeeper, helping convert soundwaves into the electrical signals that our brains interpret as sound. The finding, though incremental, helps establish a more detailed understanding of how hearing works.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue looks deep into the brains of small critters and their decision-making processes. Also: how research on rare diseases could benefit us all, and much more.


From this issue

 

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