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The genetic underpinnings of severe staph infections
...This finding was particularly surprising because, until then, specific defects in cell intrinsic immunity had only been linked to a predisposition to some viral infections, from Covid to herpes to encephalitis. It had never been shown to play a role in bacterial disease. "This is the fi...
How the body's B cell academy ensures a diverse immune response
...The findings shed new light on how the immune system mounts a response against infections such as COVID and HIV. "Germinal centers are open structures that continuously receive B cells," says Michel C. Nussenzweig, the Zanvil A. Cohn and Ralph M. Steinman Professor at Rockefeller. "As t...
Could future coronavirus variants fully dodge our immune system?
...Immunity in people who fought off COVID last year and later received mRNA vaccines is impressively broad,” says Paul Bieniasz, head of the Laboratory of Retrovirology at Rockefeller. “This tells us that although natural infection or the vaccines lead to immunity, they have in no way com...
Hundreds of new drug targets to combat tuberculosis
...COVID-19 among infectious diseases.  Now, a new study in Nature Microbiology maps the methods by which Mycobacterium tuberculosis (Mtb) bacteria shrug off antibiotics, revealing hundreds of drug targets that could strip this pathogen of its notorious resis...
Vaccines charge up natural immunity against SARS-CoV-2
According to new research, people who have had COVID enjoy strong immunity against the coronavirus for at least a year after they were initially infected. In analyzing antibodies present in the blood of COVID patients, Rockefeller scientists were able to track the evolution of these...
A never-before-seen image of the coronavirus copy machine
...In fact, some existing antivirals, as well as several new candidates under investigation specifically for COVID-19 act on RdRp—including remdesivir, which is currently being used in several countries for treatment of severe cases. These antiviral drugs try to lodge into nooks and cranni...
Scientists uncover antiviral protein that blocks coronavirus infection
...Now, a study identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The protein, known as LY6E, stops the virus from fusing with host cells. Researchers in the lab of Rockefeller’s Charles M. Rice, along with colla...
Llamas immune to coronavirus, what zebrafish are thinking, and other memorable science stories of 2020 
COVID-19 dominated scientific research this past year, with good reason. When the worst pandemic of the century struck, scientists from all disciplines banded together to fend off a virus that will have claimed at least 1.6 million lives by the new year. But basic science did not come to a...
Missing immune molecule may explain why some HPV patients sprout giant horn-like growths
...The findings play into the larger body of Casanova’s work, which continues to demonstrate that the severity of  influenza, tuberculosis, COVID-19, and other diseases, is not solely dependent on the pathogen itself, but on genetics of the host, too.
Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”
...Rice, is developing so-called monoclonal antibody treatments in which a potent antibody is identified and mass-produced to be used as medication for COVID-19. To better understand if such interventions will remain effective over time, they examined viral mutation patterns using a stand-...
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