...Prior work from the Tavazoie lab has demonstrated that these variants can play pivotal roles in how the body responds to diseases from cancer to COVID, but the link between Alzheimer's disease and APOE4 is particularly well-established: the APOE4 variant, carried by about 20 percent of ...
More than 10 percent of people who develop severe COVID-19 have misguided antibodies that attack not the virus, but the immune system itself, new research shows. Another 3.5 percent, at least, carry a specific kind of genetic mutation. In both groups, the upshot is basically the same: The ...
...Research aimed to understand how COVID-19 wreaks havoc in the lungs, for example, has often been done with miscellaneous lung cancer cells that show crucial differences with the cells targeted by the virus. “There has been too much shifting ground for precise work,” says Ali H. Brivanlo...
Rockefeller University experts in infectious disease, immunology, biochemistry, structural biology, and genetics have begun over a dozen projects in recent weeks aimed at better understanding the biology of the SARS-CoV-2 virus, which is responsible for the current global COVID-19 pandemic...
In more ways than one, antibodies could be the key to alleviating the COVID-19 crisis. Hundreds of labs around the world are studying the antibodies people produce in response to SARS-CoV-2 infection in hopes of developing treatments, predicting the efficacy of vaccines, and understanding...
...Casanova, along with Helen Su at the National Institute of Allergy and Infectious Diseases are leading an international project, the COVID Human Genetic Effort, to comb through the genomes of many COVID-19 outliers in search of any rare gene variant that they may share, and that ...
...In recent studies, elevated IL24 activity has been spotted in epithelial lung tissue of patients with severe COVID-19 and in colonic tissue in patients with ulcerative colitis, a chronic inflammatory bowel disease. “IL24 could be working as a cue to signal the need for injury repair in ...
...The dysregulation of the contact system is involved in COVID, sickle cell anemia, hereditary angioedema, inflammatory bowel disease, sepsis, lupus, arthritis, and even cancer metastasis,” she says.
In the few weeks since New York City came to a socially distanced halt, more than 250 COVID-19 survivors have visited Rockefeller’s otherwise quiet campus to contribute their blood to science. Here, a group of immunologists, medical scientists, and virologists is betting that a cure for th...
As the world faces an impending wave of COVID cases due to Omicron, scientists are racing to assess vaccine efficacy against the new variant. In a new study, Rockefeller scientists report on their comprehensive analysis of Omicron’s resistance to antibodies, offering insights about the lev...
