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Displaying 57 of 2876 articles.

How toothless mock viruses could advance research on COVID-19

In more ways than one, antibodies could be the key to alleviating the COVID-19 crisis.  Hundreds of labs around the world are studying the antibodies people produce in response to SARS-CoV-2 infection in hopes of developing treatments, predicting the efficacy of vaccines, and understanding...

New evidence that boosters may be crucial in protecting against Omicron

As the world faces an impending wave of COVID cases due to Omicron, scientists are racing to assess vaccine efficacy against the new variant. In a new study, Rockefeller scientists report on their comprehensive analysis of Omicron’s resistance to antibodies, offering insights about the lev...

Scientists are using ‘elite’ antibodies from COVID-19 survivors to develop potent therapies

In the few weeks since New York City came to a socially distanced halt, more than 250 COVID-19 survivors have visited Rockefeller’s otherwise quiet campus to contribute their blood to science. Here, a group of immunologists, medical scientists, and virologists is betting that a cure for th...

The genetic underpinnings of severe staph infections

...This finding was particularly surprising because, until then, specific defects in cell intrinsic immunity had only been linked to a predisposition to some viral infections, from Covid to herpes to encephalitis. It had never been shown to play a role in bacterial disease. "This is the fi...

How the body's B cell academy ensures a diverse immune response

...The findings shed new light on how the immune system mounts a response against infections such as COVID and HIV. "Germinal centers are open structures that continuously receive B cells," says Michel C. Nussenzweig, the Zanvil A. Cohn and Ralph M. Steinman Professor at Rockefeller. "As t...

Hundreds of new drug targets to combat tuberculosis

...COVID-19 among infectious diseases.  Now, a new study in Nature Microbiology maps the methods by which Mycobacterium tuberculosis (Mtb) bacteria shrug off antibiotics, revealing hundreds of drug targets that could strip this pathogen of its notorious resis...

Could future coronavirus variants fully dodge our immune system?

...Immunity in people who fought off COVID last year and later received mRNA vaccines is impressively broad,” says Paul Bieniasz, head of the Laboratory of Retrovirology at Rockefeller. “This tells us that although natural infection or the vaccines lead to immunity, they have in no way com...

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Vaccines charge up natural immunity against SARS-CoV-2

According to new research, people who have had COVID enjoy strong immunity against the coronavirus for at least a year after they were initially infected. In analyzing antibodies present in the blood of COVID patients, Rockefeller scientists were able to track the evolution of these...

A never-before-seen image of the coronavirus copy machine

...In fact, some existing antivirals, as well as several new candidates under investigation specifically for COVID-19 act on RdRp—including remdesivir, which is currently being used in several countries for treatment of severe cases. These antiviral drugs try to lodge into nooks and cranni...

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Scientists uncover antiviral protein that blocks coronavirus infection

...Now, a study identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The protein, known as LY6E, stops the virus from fusing with host cells. Researchers in the lab of Rockefeller’s Charles M. Rice, along with colla...