Skip to main content
Displaying 57 of 2876 articles.

"Exhausted" immune cells may drive Alzheimer's

...Prior work from the Tavazoie lab has demonstrated that these variants can play pivotal roles in how the body responds to diseases from cancer to COVID, but the link between Alzheimer's disease and APOE4 is particularly well-established: the APOE4 variant, carried by about 20 percent of ...

Lab-grown mini lungs could accelerate the study of respiratory diseases  

...Our understanding of how infectious diseases like COVID affect human lungs has been similarly confounded by noise. Data from patient lung tissues greatly varies from person to person, obscuring the basic mechanisms of how, exactly, SARS-Co-V2 first infects lung cells. It’s also an after...

Natural infection versus vaccination: Differences in COVID antibody responses emerge

...Hope for a future without fear of COVID-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And t...

COVID-19 immunology study reveals universally effective antibodies

...A study of 149 people who have recovered from COVID-19 shows that although the amount of antibodies they generated varies widely, most individuals had generated at least some that were intrinsically capable of neutralizing the SARS-CoV-2 virus. The findings are published June 18 in the ...

Rockefeller saliva test for COVID-19 outperforms commercial swab tests

In the early days of the pandemic, with commercial COVID tests in short supply, Rockefeller’s Robert B. Darnell developed an in-house assay to identify positive cases within the Rockefeller community. It turned out to be easier and safer to administer than the tests available at the time, ...

Researchers reveal an ancient mechanism for wound repair

...In recent studies, elevated IL24 activity has been spotted in epithelial lung tissue of patients with severe COVID-19 and in colonic tissue in patients with ulcerative colitis, a chronic inflammatory bowel disease. “IL24 could be working as a cue to signal the need for injury repair in ...

An immune flaw may cause West Nile virus’s deadliest symptoms

...West Nile virus now joins a small but important group of infectious diseases with a documented link between interferon-neutralizing autoantibodies and cases resulting in the most severe or deadly symptoms, including influenza (5%), COVID (15%), and MERS pneumonia (25%). But with 40% of ...

COVID-19 vaccines may need regular updates for emerging variants

...Soon after the world’s first COVID-19 vaccination campaigns kicked off, news emerged about new, more contagious SARS-CoV-2 variants crisscrossing the planet. The discovery of such strains in Britain, Brazil, and South Africa has raised a pressing concern: Will current vaccines be effect...

A unique window into "original antigenic sin"

...Scientists call this original antigenic sin (OAS)—the body's first blush with a virus like influenza or COVID being the "original sin" that forever biases its immune response against newer strains. According to the OAS theory, no matter how many flu vaccines or COVID boosters we ...

Unlocking how the new Alzheimer’s drug lecanemab works

...The dysregulation of the contact system is involved in COVID, sickle cell anemia, hereditary angioedema, inflammatory bowel disease, sepsis, lupus, arthritis, and even cancer metastasis,” she says.