A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.
Fuchs receives the honor for illuminating the genetics of skin diseases and the mechanisms that guide skin renewal, yielding insights into aging, inflammation, and cancer.
A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus.
