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Updates on the University COVID-19 response and operations available here.
Displaying 142 of 2778 articles.

Colorectal cancer tumors both helped and hindered by T cells

Researchers have long disagreed over whether 𝛄𝛅T cells in the gut promote or discourage tumor growth, but new evidence suggests they have the capacity to do both.

A third vaccine dose may increase protection from Omicron

The booster appears to galvanize memory B cells into producing potent and versatile antibodies that neutralize both the original virus and its many variants.

Titia de Lange elected to the Royal Society

She receives the honor for elucidating mechanisms of telomere protection and genome maintenance.

Kivanç Birsoy, expert on cancer cell metabolism, is promoted to associate professor 

Birsoy's groundbreaking research has highlighted key nutrients that cancer cells need to survive, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.

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New comprehensive map of the portal to the cell’s nucleus

The findings, which may have implications for a wide range of human diseases, suggest that nuclear pore complexes vary in structure and function even within a single nucleus.

New evidence that boosters may be crucial in protecting against Omicron

Researchers found that the antibodies present in people who have had COVID or taken two doses of mRNA vaccine are inadequate against Omicron. But their protective ability increases significantly after a booster dose.

Llama antibodies could help fight SARS-CoV-2 variants

Scientists have identified hundreds of llama-derived antibodies that potentially could be developed into a COVID treatment. They hope such a drug would be potent against different variants of the coronavirus, including Omicron.

Radiotherapy may explain why childhood cancer survivors often develop metabolic disease

Radiation therapy to treat childhood cancer may damage adipose tissue, causing diabetes and coronary heart disease decades later.

Scientists discover how mitochondria import antioxidants

The finding offers researchers a direct way to investigate oxidative stress and its damaging effects in aging, cancer and other diseases.

How foodborne diseases protect the gut's nervous system

Prior infections appear to shield enteric neurons, preventing these key components of the body's "second brain" from dying off when future pathogens strike.

Noninfectious versions of SARS-CoV-2 provide powerful research tools

The new experimental system will facilitate efforts to study different coronavirus variants and develop new drugs for
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  • Small molecule may prevent metastasis in colorectal cancer

    The compound works by hindering a key pathway that cancer cells rely upon to hoard energy, and is already undergoing clinical trials.


    Study detects origins of Huntington's disease in two-week-old human embryos

    The findings shed new light on the root causes of this disease, which leads to the degeneration of neurons in midlife.

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    Novel method for trapping HIV inside its host may give rise to new antivirals

    Human cells can be coaxed into preventing certain enveloped viruses (including HIV, Ebola, and parainfluenza) from escaping their membranes in the lab, a finding that could lead to novel treatments for many viral diseases.

    Could future coronavirus variants fully dodge our immune system?

    Studying dozens of naturally occurring and laboratory-selected mutations in SARS-CoV-2, researchers found that the virus will need to pull off a genetic feat to become fully resistant to antibodies.

    Toward the first drug to treat a rare, lethal liver cancer

    After scouring more than 5,000 compounds, scientists have identified several new classes of therapeutics that may help treat fibrolamellar carcinoma.

    New findings to boost IVF success rates

    New research casts doubt on a genetic test used to screen would-be embryos for IVF implantation. The findings suggests that these embryos can develop into healthy babies regardless of whether or not they’ve been flagged as defective by the test.

    Paul Cohen, expert on fat, is promoted to associate professor

    Cohen, a physician-scientist exploring obesity and metabolic disease, has conducted groundbreaking research on the complex inner workings of fat tissue.

    Immunologist Daniel Mucida promoted to professor

    A pioneer in the field of mucosal immunology, Mucida is unlocking the secrets of the digestive system and answering fundamental questions about the origins of human disease.

    Synthetic “micro lungs” could take COVID-19 research to the next level

    Scientists have developed stem-cell technology to mass-produce tissue cultures resembling our breathing organs. These tissues offer a powerful model in which to study how SARS-CoV-2 wreaks havoc in the lungs and to screen for new drugs.

    As COVID-19 vaccines emerge, the search for antiviral drugs continues

    Scientists are digging through drug libraries of 430,000 compounds, in pursuit of an antiviral drug that can stop the novel coronavirus in its tracks.

    Scientists map the network of SARS-CoV-2’s helpers inside human cells

    The virus must hijack a more than a hundred human proteins to replicate inside a cell. One of them stands out because it is an absolute requirement for infection by four different coronaviruses as well as by viruses that cause Zika, yellow fever, and other diseases.

    Rockefeller issues license for the development of novel anti-inflammatory drug

    The novel compound, discovered in Jan L. Breslow’s lab and now licensed to Bridge Medicines, will be designed to treat immune-mediated diseases without harming the rest of the immune system.

    Rockefeller's Charles M. Rice honored with Nobel Prize for research that contributed to a cure for hepatitis C

    Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...

    Cancer cells use nerve-cell tricks to spread from one organ to the next

    New research suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments.

    Microbes in the gut may influence metabolism

    A growing number of studies find that microbes in the gut directly influence biological processes from bowel movements to behavior. New research reveals how they impact levels of glucose in the blood.

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    Scientists uncover antiviral protein that blocks coronavirus infection

    New research identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The findings could inform treatment strategies and help us better prepare for future outbreaks.

    Study uncovers the molecular events by which popular antidepressants work

    Scientists have outlined a molecular program by which serotonin reuptake inhibitors reshape the brain to alleviate depression. Their findings provide clues for how to make better and faster-acting versions of these drugs.

    Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

    Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...


    How toothless mock viruses could advance research on COVID-19

    Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.
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