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Kivanç Birsoy is uncovering the hidden metabolic pathways that cancer cells exploit. His work could also optimize strategies for using nutrition to improve human health.

Open access, peer reviewed, and co-owned, the Journal of Human Immunity represents a new business model in scientific publishing.

A surprising mix of inherited and de novo mutations in 60 genes contribute to 10 percent of CHD cases. Many of these same mutations also contribute to neurodevelopmental disorders including autism. 

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations.

Jeffrey M. Friedman’s lab has discovered a mechanism to explain how leptin resistance works.

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

A collaboration between Rockefeller, MSK, and Weill Cornell answers a longstanding mystery about the basic biology of the hepatitis B virus, while also proposing a novel therapy.

When placed in mice, an RNA-binding protein found only in the brains of humans changed how the animals vocalized to each other.

How much does the evolution of human speech owe to one amino acid?

New research on nematodes reveals how glial cells maintain and monitor neuronal dendrites.

A newly created atlas of 21 million cells could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies.

New insights could fine-tune this immunotherapy to avoid a common side effect without sacrificing efficacy.

An autoimmune condition makes certain people much more susceptible to West Nile virus and many other severe viral diseases. In the future, a screening process could reveal if you’re at risk.  

The study explains why treatments for many autoimmune and inflammatory diseases raise the risk of contracting TB—and also upends long-held assumptions about what kicks off an immune response.      

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1.

In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.

The end replication problem dictates that telomeres shrink unless telomerase intervenes. But the problem is actually twice as complicated, with telomerase providing only part of the solution.

Telomerase could run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage.

Marraffini is honored for his pioneering research on the study of CRISPR-Cas systems.

The absence of a single immune cell receptor has been linked to both fewer defenses against mycobacterial infections, such as TB, and damaging buildup of sticky residue in the lungs.  

It also reduces the cost of a million single-cell transcriptomes from $10,000 to $700—and the time necessary down to about a day.

The novel technique may offer panoramic view into the mechanisms of many diseases and the enigma of aging.

The better a songbird is at working its way around obstacles to retrieve a snack, the more complex its vocal learning ability will be.

Birsoy is honored for groundbreaking research uncovering metabolic weaknesses of diseased cells, such as cancer, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.

With 40% of encephalitis cases now explained by an autoimmune deficiency, West Nile virus "is by far the best understood human infectious disease in the world. It’s stunning.”

The human reference genome has always been a remarkable but flawed tool. A new "pangenome" aims to correct its oversights and omissions.

A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.

A new study suggests that stem cells are able to integrate cues from their surroundings and coordinate their behavior across tissue through networks of vasculature in their close vicinity.

The human reference genome, the most widely used resource in human genetics, is getting a major update.

A mutated gene may explain why some Staphylococcus aureus infections turn lethal, a finding with significant implications for people living with 5p- syndrome.
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