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In Brief

New research shows that mosquitoes sense repellent through their legs

Scientists made the surprising discovery that the insects’ displeasure for touching DEET, the active ingredient in many repellents, helps prevent bites.
Bacteriophages inject their DNA into bacteria, typically resulting in the bacterium’s demise. CRISPR-Cas systems defend bacteria against these attacks.
Science News

To curb infection, bacteria direct their defenses against themselves

To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
Here, a winner (red) engulfs a loser (green)
Science News

Cellular rivalry promotes healthy skin development

Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
Science News
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In Brief

Researchers find genetic link to tuberculosis

Rockefeller scientists have identified a genetic condition that makes people prone to developing tuberculosis. In a British population, they found that the condition underlies one percent of cases of the disease—a finding that may ultimately lead to new treatment options.
Science News
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In Brief

Study explores genetic differences among people’s gut microbes, and their health consequences

Scientists have found that small genetic differences can cause the same gut microbe to behave differently in different people, and affect the overall health of their human hosts.
Human astrocytes
Science News

Research on repetitive worm behavior may have implications for understanding human disease

Studying microscopic worms, Rockefeller scientists have identified a brain circuit that drives repetitive behavior—providing potential clues for understanding some human psychiatric conditions.
Tumor stem cells
Science News

Study pinpoints what causes relapse after cancer immunotherapy

In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
DIPG cells, pictured here, are generally resilient and replicate rapidly. With a dose of MI-2, however, the cells abruptly die.
Science News

New hope for treating a childhood brain cancer

Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
Activation of hD2R neurons
Science News

Scientists find brain mechanism that naturally combats overeating

Studying a brain region involved in memory, researchers discovered a set of neurons that help mice control their appetite.
Science News
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In Brief

Researchers discover a common link among diverse cancer types

Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
Science News
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In Brief

Scientists find new clues about how the body stores fat

Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.
Leptin mouse
Science News

Scientists identify genetic factors that may cause some people to become obese

New research on leptin, a hormone that regulates appetite, reveals a previously unknown mechanism that may be responsible for at least 10 percent of obesity cases. The findings could help identify individuals with treatable forms of the condition.
C. elegans
Science News

Inside the brains of hungry worms, researchers find clues about how they hunt

When looking for food, the roundworm C. elegans searches the same area for up to 20 minutes before trying its luck at more distant locales. New research on the worm’s brain explains how this behavior arises at the level of molecules and cells.
An excess of squalene (pink)—
Science News

Researchers discover a weakness in a rare cancer that could be exploited with drugs

Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.
Mosquitos illustration
Science News

New findings could make mosquitoes more satisfied—and safer to be around

Scientists have learned new tricks that could be useful in preventing mosquito-borne illnesses such as Zika and yellow fever. A new study shows that some appetite-reducing drugs can curtail the insects’ impulse to feed on warm-blooded hosts.
Jeff Friedman
Awards and Honors, Campus News

Jeffrey M. Friedman to receive the 2019 Wolf Prize in Medicine

Friedman receives the award for his discovery of leptin, a hormone that modulates food intake and energy expenditure.
Geckos move through water they slap their arms, generating air bubbles that help them stay afloat.
Science News

Study explains how geckos gracefully gallop on water

Geckos are amazingly agile. In addition to running across land and up trees, the animals can prance across the surface of water. A new study reveals how they do it.
Though small and seemingly simple organisms, bacteria are equipped with effective, multifaceted immune systems.
Science News

Shape-shifting protein protects bacteria from invaders

Researchers have discovered how bacteria manage to destroy enemy DNA, while keeping their own genetic material safe.
Leslie B. Vosshall (left) and Ben Matthews (right).
Science News

Mosquito genome opens new avenues for reducing bug-borne disease

Researchers have assembled a new and improved DNA catalogue for the mosquito Aedes aegypti. This tool will help researchers understand the insect’s biology, and may lead to new strategies for preventing diseases like Zika and dengue.
Photo of River Campus
Campus News

Fundraising campaign surpasses goal two years ahead of schedule

Launched in 2011, the university’s Campaign for Transforming Biomedicine has raised $1.059 billion as of September 30 this year.
Snow at Rockefeller
Campus News

University updates policy on storm-related closures

Beginning this winter, Rockefeller will close during days that New York City public schools close due to weather emergencies.
When lab-grown embryos were exposed to Activin alone, they failed to differentiate (left). Following exposure to both WNT and Activin, distinct cell types emerged (right).
Science News

Embryos remember the chemicals that they encounter

A new study shows that embryonic cells retain a memory of the chemical signals to which they are exposed. Without these memories, cells fail organize into distinct tissue types.
Science News
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In Brief

New gene-engineering technique will help scientists study the immune system

Using gene editing technology, researchers have developed a new way to study B cell activation in mice. This technique makes research more efficient, and has the potential to improve our understanding of immune responses in humans.
Science News
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In Brief

Genetic mutation identified as culprit in rare infectious disease

Researchers have uncovered the genetic factors that make some people susceptible to Whipple's disease, an intestinal inflammatory disorder that causes diarrhea, pain, and weight loss.
Equipment in Nussenzweig lab
Awards and Honors

Gaby Maimon and Luciano Marraffini are named HHMI investigators

Maimon, who studies cognition and decision-making, and Marraffini, who studies the bacterial defense system CRISPR-Cas, are among 19 scientists nationwide to receive this designation.
A dying tail-spike cell
Science News

What happens to a dying cell’s corpse? New findings illuminate an old problem

Scientists have discovered a curious way for cells to die. In studying it, they are learning about how remnants of diseased cells are normally chewed up and removed.
Science News
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In Brief

In brief: Tweaking RNA protects cells from harmful inflammation

New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.
Science News
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In Brief

In brief: Mutation explains why some people are more vulnerable to viral brain infection

Scientists identified mutations in a single gene that impair immunity to viruses in a region of the brain called the brain stem.
C elegans w
Science News

Scientists shed light on biological roots of individuality

A new study illuminates the biology that guides behavior across different stages of life in worms, and suggests how variations in specific neuromodulators in the developing nervous system may lead to occasional variations.
A new labeling technique in Victora's lab
Science News

New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.
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