Thomas Tuschl has devoted his career to making discoveries that bridge the gap between bench and business—and have resulted in entirely new classes of drugs.
The end replication problem dictates that telomeres shrink unless telomerase intervenes. But the problem is actually twice as complicated, with telomerase providing only part of the solution.
“I believe this is going to be a very fruitful find. Every time people have studied nutrient sensing, we’ve learned a lot about biology, and many drugs have been developed as a result.”
Birsoy is honored for groundbreaking research uncovering metabolic weaknesses of diseased cells, such as cancer, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.
A new study suggests that stem cells are able to integrate cues from their surroundings and coordinate their behavior across tissue through networks of vasculature in their close vicinity.
The booster appears to galvanize memory B cells into producing potent and versatile antibodies that neutralize both the original virus and its many variants.
Unlike conventional antiretroviral drugs, treatment with broadly neutralizing antibodies does not rely on vigilant daily dosing and could potentially reduce the body’s reservoir of latent viruses.
Birsoy's groundbreaking research has highlighted key nutrients that cancer cells need to survive, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.
Researchers found that the antibodies present in people who have had COVID or taken two doses of mRNA vaccine are inadequate against Omicron. But their protective ability increases significantly after a booster dose.
New research reveals how neurons in a fly's brain signal the direction in which the body is traveling. The cells appear to literally perform vector math in order to act as a biological compass.
Epidermal stem cells that hail from the hair follicle retain memories of their journey to the skin's surface. Those memories are a boon for wound repair, but may also contribute to chronic diseases and cancer.
Human cells can be coaxed into preventing certain enveloped viruses (including HIV, Ebola, and parainfluenza) from escaping their membranes in the lab, a finding that could lead to novel treatments for many viral diseases.
A new study finds that proteins known as linker histones control the complex coiling process that determines whether DNA will wind into long and thin chromosomes, made up of many small loops, or short and thick chromosomes with fewer large loops.
Studying dozens of naturally occurring and laboratory-selected mutations in SARS-CoV-2, researchers found that the virus will need to pull off a genetic feat to become fully resistant to antibodies.
If COVID-19 lockdowns scrambled your sleep schedule and stretched your waistline, you're not alone. Fruit flies quarantined in test tubes sleep too little and eat too much after only one week of social isolation.
Cohen, a physician-scientist exploring obesity and metabolic disease, has conducted groundbreaking research on the complex inner workings of fat tissue.
Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system.
In a painstaking experiment, scientists suspended a single protein filament between two microscopic beads. Their results have shed light on an elusive process in which cells receive and respond to mechanical cues.
Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
A new molecular structure explains how cells hold an alarm-triggering protein captive during cell division, preventing cells from targeting their own DNA.
Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the di...
Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...
In findings that might lead to better smoking-cessation tools, scientists have shown that manipulating a specific brain receptor can alter a mouse’s nicotine sensitivity.
Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Scientists have identified the mechanism that allows skin cells to sense changes in their environment, and very quickly respond to reinforce the skin's outermost layer. The findings provide insight into how errors in this process might lead to skin conditions like psoriasis.
The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
Scientists have identified a particular type of skin cell that looks and behaves similar to a nerve cell, prompting new questions about the body's biggest organ.
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Protein clumps are routinely found in the brains of patients with neurodegenerative diseases. Now researchers find a link between this buildup and the intracellular movement of proteasomes, molecular machines tasked with degrading protein waste inside cells.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
In studying cell division, scientists happened upon a new way of understanding how a chemotherapy compound works. The findings could make it possible to predict which patients are most likely to benefit from the drug.
Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.
To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
Studying microscopic worms, Rockefeller scientists have identified a brain circuit that drives repetitive behavior—providing potential clues for understanding some human psychiatric conditions.
In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
