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DIPG cells, pictured here, are generally resilient and replicate rapidly. With a dose of MI-2, however, the cells abruptly die.
Science News

New hope for treating a childhood brain cancer

Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
Intestine
Science News

New approach to treating gastrointestinal disease patches up leaky intestines

Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  
Science News
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In Brief

Researchers discover a common link among diverse cancer types

Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
Science News
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In Brief

Scientists find new clues about how the body stores fat

Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.
An excess of squalene (pink)—
Science News

Researchers discover a weakness in a rare cancer that could be exploited with drugs

Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.
Jeff Friedman
Awards and Honors, Campus News

Jeffrey M. Friedman to receive the 2019 Wolf Prize in Medicine

Friedman receives the award for his discovery of leptin, a hormone that modulates food intake and energy expenditure.
Geckos move through water they slap their arms, generating air bubbles that help them stay afloat.
Science News

Study explains how geckos gracefully gallop on water

Geckos are amazingly agile. In addition to running across land and up trees, the animals can prance across the surface of water. A new study reveals how they do it.
Though small and seemingly simple organisms, bacteria are equipped with effective, multifaceted immune systems.
Science News

Shape-shifting protein protects bacteria from invaders

Researchers have discovered how bacteria manage to destroy enemy DNA, while keeping their own genetic material safe.
Researchers have mapped more than 20 different cell types present in the first-trimester human placenta, including stromal and endothelial cells (red).
Science News

First mapping of cells in the early human placenta to advance research on problem pregnancies

Scientists have made the first comprehensive inventory of cells present in the human placenta of the first trimester, a stage when many pregnancy complications are thought to arise. The findings could fuel new research on conditions such as preeclampsia and pre-term birth.
The researchers studied neurons from the cerebellum, a brain region involved in coordinating movement. Photo credit: Elitsa Stoyanova and Maria V. Moya
Science News

New method for studying gene expression could improve understanding of brain disease

By analyzing gene expression patterns, researchers have identified previously unknown distinctions between mouse and human neurons. They have also developed a new way to track cellular changes associated with brain disorders.
Science News
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In Brief

Enzyme structure helps to explain how protein factories are constructed

Researchers characterized the structure of Mdn1, an enzyme key to making ribosomes.
Equipment in Nussenzweig lab
Awards and Honors

Gaby Maimon and Luciano Marraffini are named HHMI investigators

Maimon, who studies cognition and decision-making, and Marraffini, who studies the bacterial defense system CRISPR-Cas, are among 19 scientists nationwide to receive this designation.
A dying tail-spike cell
Science News

What happens to a dying cell’s corpse? New findings illuminate an old problem

Scientists have discovered a curious way for cells to die. In studying it, they are learning about how remnants of diseased cells are normally chewed up and removed.
Scientists map the portal to the cell’s nucleus
Science News

Scientists map the portal to the cell’s nucleus

The gateway to cellular headquarters has 552 components. A new map that shows how all these pieces fit together could help scientists study numerous diseases.
A cross section of a metastatic brain tumor from a patient
Science News

Scientists caution that a rare childhood liver cancer can spread to the brain

A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.
Science News
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In Brief

In brief: Tweaking RNA protects cells from harmful inflammation

New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.
Günter Blobel
Campus News

Günter Blobel, a Nobel laureate who redefined cell biology, has died

Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.
Science News

In brief: New molecular insights on a rare immune disorder

After figuring out the functions of two proteins involved in the rare genetic condition ICF, scientists pieced together the molecular process that is altered in the disease.
Science News
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In Brief

In brief: How the immune system curbs its own mistakes

Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.
neural projections within fat tissue
Science News

3D imaging of fat reveals potential targets for new obesity treatments

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.
Science News

In brief: New clues about how cells restart stalled replication

Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.
Amigo1 Cell
Science News

Brain research points the way to new treatments for nicotine addiction

Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.
Nussenzweig portrait
Awards and Honors

Michel C. Nussenzweig wins 2017 Sanofi-Institut Pasteur Award

Nussenzweig was honored at a ceremony today at the Institut Pasteur in Paris.The award recognizes investigators for past or ongoing work demonstrating real scientific progress in the life sciences.
Michael Young portrait
Awards and Honors

Michael W. Young receives 2017 Nobel Prize in Physiology or Medicine

Young was honored for his discoveries of molecular mechanisms controlling the circadian rhythm. He accepted the Nobel medal and diploma from King Carl XVI Gustaf of Sweden.
Mutant worm brain
Science News

Glial cells, not neurons, lead the way in brain assembly

Researchers have found that the cells directing the very first steps of brain formation are not other neurons, as scientists have long assumed. They've also uncovered previously hidden molecular pathways that attract neurons into the brain.
Science News
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In Brief

In brief: A close look at how HIV-fighting proteins slow the virus down

A new study sheds light on how the body fights back against HIV by mutating the viral DNA.
New study points the way to therapy for rare cancer that targets the young
Science News

New study points the way to therapy for rare cancer that targets the young

Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.
A human cell (green) infected with HIV (red)
Science News

In the fight against viral infection, spelling counts

Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible to develop safer vaccines.
Measles virus is suppressed
Science News

Targeting a single protein might treat a broad range of viruses

Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.
Fragile X brain
Science News

Potential new treatment for Fragile X targets one gene to affect many

Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.
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