Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
A new molecular structure explains how cells hold an alarm-triggering protein captive during cell division, preventing cells from targeting their own DNA.
Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the di...
Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...
In findings that might lead to better smoking-cessation tools, scientists have shown that manipulating a specific brain receptor can alter a mouse’s nicotine sensitivity.
Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Scientists have identified the mechanism that allows skin cells to sense changes in their environment, and very quickly respond to reinforce the skin's outermost layer. The findings provide insight into how errors in this process might lead to skin conditions like psoriasis.
The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
Scientists have identified a particular type of skin cell that looks and behaves similar to a nerve cell, prompting new questions about the body's biggest organ.
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Protein clumps are routinely found in the brains of patients with neurodegenerative diseases. Now researchers find a link between this buildup and the intracellular movement of proteasomes, molecular machines tasked with degrading protein waste inside cells.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
In studying cell division, scientists happened upon a new way of understanding how a chemotherapy compound works. The findings could make it possible to predict which patients are most likely to benefit from the drug.
Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.
To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
Studying microscopic worms, Rockefeller scientists have identified a brain circuit that drives repetitive behavior—providing potential clues for understanding some human psychiatric conditions.
In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
