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Displaying 176 of 2899 articles.

Cancer cells may be using lipids to hide from the immune system

New study demonstrates that one type of lipid is so critical for immune evasion that certain cancers cannot proliferate without them. Modulating intake of dietary lipids could open up an avenue for treatment.

This technique for studying cell receptors could have sweeping implications for drug development

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors.

Second genetic sensor for DNA methylation discovered

CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA.

New genetic tool could identify drug targets for diseases associated with metabolic dysfunction

A novel platform for identifying metabolic gene functions has already revealed interactions between proteins and metabolites that are fundamental to cell metabolism.

Key mechanism for maintaining proper telomere length identified 

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1.

How one scientist's fascination with RNA changed medicine forever

Thomas Tuschl has devoted his career to making discoveries that bridge the gap between bench and business—and have resulted in entirely new classes of drugs.

Double trouble at chromosome ends

The end replication problem dictates that telomeres shrink unless telomerase intervenes. But the problem is actually twice as complicated, with telomerase providing only part of the solution.

Cutting-edge methods yield surprising insights into Huntington’s disease

New findings add depth to our understanding of neurodegeneration.

Keeping telomerase in check

Telomerase could run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage.

Luciano Marraffini wins Vilcek Prize in Biomedical Science

Marraffini is honored for his pioneering research on the study of CRISPR-Cas systems.
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