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Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. More info here.

Compound Libraries

Diversity Analysis The HTSRC curates and annotates a small molecule library containing 389,728 natural products, low molecular weight screening compounds, pharmacologically active compounds, clinically used compounds and compound fragments.

Quality Measurements

381,815 compounds = N mean sd min max median
LogD 2.8 1.6 -30 19 2.8
Number of Rotatable Bonds 5.2 2.3 0 43 5
Molecular Weight 373.5 76 7 2554 370
Polar Surface Area 79.5 28 0 1000 77
log Solubility (m/L) -4.8 1.7 -21 4 -4.8
log partition coefficent 3.0 1.5 -13.2 18.8 3
Number of H-bond Acceptors 4.2 1.5 0 51 4
Number of H bond Donors 0.9 0.8 0 36 1
Quantitative Estimate of Drug-likeness (QED) 0.7 0.2 0 0.9 0.7
Formal Charge 0.0 0.005 -3 3 0
fraction of sp3 hybridized carbons 0.35 0.18 0 1 0.3
synthetic accessibility score 0.25 0.07 -0.8 0.4 0.25
Heavy Atom count 25.9 5.4 1 181 26

HTS Libraries

AnalytiCon Natural Products (700 compounds)
ChemBridge  (63,000 compounds)
ChemDiv  (122,000 compounds)
Enamine (128,000 compounds)
Edelris Natural Product-like (2000 compounds)
Life Chemicals (80,000 compounds)

Drug Repurposing Libraries

Our repurposing compound libraries consist of  9747 samples representing 7043 compounds. These compounds are well-suited for studies of drug re-purposing, tool compound re-purposing and target identification. This collection contains 1294 legally approved drugs from Japan, Europe and North America; 756 investigational drugs which have been tested in clinical trials; 4937 pre-clinical compounds which appear in peer-reviewed published research or patents. The compounds were purchased from the following vendors:

LOPAC1280™ (1280 compounds)
MicroSource/Pharmacon  (2,900 compounds)
The Prestwick Chemical Library® (1120 compounds)
NIH Clinical Collection (727 compounds)
Tocriscreen Compounds (480 compounds)
HTSRC Clinical Collection (303 compounds)
Selleck Bioactive Compounds (2937 compounds)

Fragment-based Screening Libraries
Life Chemicals  (1056 compounds with measured solubility)

Open Reading Frames
The HTSRC has a collection of 17,000 DNA plasmids representing individual proteins in the human genome. The plasmids are in carried in E. coli glycerol stocks, and can be used for protein expression using Gateway vector systems along with Lentiviral packaging constructs. Two versions are available. The Precision ORF collection is contained in a pLOC vector which carries blasticidin resistance and a GFP IRES-driven marker for positive clone selection.  The second version is the CCSB Broad Lenti ORF library, of 16100 clones in a pLX304 vector containing blasticidin resistance, GFP marker and a stop codon after a v5 epitope tag.

RNAi Libraries
The Silence Select Human Kinase siRNA Library V4 (catalog no. 4397918) from ThermoFisher Scientific contains 2127 unique siRNA (0.25 nmol) targeting each of 709 human kinase genes.

Initiating a Project
If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic instruments please contact Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can accept projects from outside institutions only on a case-by-case basis.  The HTSRC does not currently support research in conjunction with for-profit entities.