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Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. More info here.

Instruments and Techniques

The HTSRC has the capability to support cellular and biochemical assays using absorbancefluorescent kinetics, fluorescence anisotropy, time-resolved fluorescence, time-resolved fluorescence resonance energy transferAlphaScreen, bioluminescence, for example luciferase and green fluorescent protein, scintillation proximity, cellular fluorescence imaging and SPE-Mass Spectrometer. Assay targets can include ion channelsreceptorsenzymesprotein interactions, signaling pathways and cellular processes.

The following instruments are available for small molecule/target analysis: a  microscale thermophoresis instrument, a circular dichroism spectrometer (CD), a surface plasmon resonance instrument (SPR), an (ITC), a high throughput Dynamic Light Scattering Instrument, and a differential scanning fluorimetry (thermal melt analysis) instrument.

Initiating a project with us

If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic instruments please contact htsrc@rockefeller.edu. Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can accept projects from outside institutions only on a case-by-case basis.  The HTSRC does not currently support research in conjunction with for-profit entities.



Contact

The Rockefeller University
Box 203
1230 York Ave
New York, NY 10065

High-Throughput Screening Resource Center
Bronk Laboratory
DWB Room 216