Instruments and Techniques
The HTSRC has the capability to support cellular and biochemical assays using absorbance, fluorescent kinetics, fluorescence anisotropy, time-resolved fluorescence, time-resolved fluorescence resonance energy transfer, AlphaScreen, bioluminescence, for example luciferase and green fluorescent protein, scintillation proximity, cellular fluorescence imaging and SPE-Mass Spectrometer. Assay targets can include ion channels, receptors, enzymes, protein interactions, signaling pathways and cellular processes.
The following instruments are available for small molecule/target analysis: a microscale thermophoresis instrument, a circular dichroism spectrometer (CD), a surface plasmon resonance instrument (SPR), an (ITC), a high throughput Dynamic Light Scattering Instrument, and a differential scanning fluorimetry (thermal melt analysis) instrument.
Initiating a project with us
If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic instruments please contact email@example.com. Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can accept projects from outside institutions only on a case-by-case basis. The HTSRC does not currently support research in conjunction with for-profit entities.