Safeguarding Accurate Chromosome Segregation: Mechanistic Insights
- This event already took place in April 2025
- Carson Family Auditorium (CRC)
Event Details
- Type
- Other Seminars
- Speaker(s)
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Arockia Jeyaprakash Arulanandam, Ph.D., professor of structural cell biology, co-head, Institute of Cell Biology, The University of Edinburgh
- Speaker bio(s)
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Abstract: Accurate transfer of genetic information through generations is essential for the survival of all forms of life. The centromere is a specialised chromosomal locus that ensures accurate chromosome segregation during cell division by acting as a microtubule attachment site by assembling a large multi-subunit protein complex called the kinetochore. The centromere is defined by the enrichment of a histone H3 variant CENP-A containing nucleosomes. The centromere also acts as a landing platform for various mitotic regulators that monitor chromosome-microtubule attachments and regulate timely onset of chromosome segregation. Any defects in the maintenance of centromere identity or function will lead to chromosome segregation errors causing aneuploidy, implicated in cancers. In this talk, I will discuss some of our recent work combining structural and cellular approaches that provided critical mechanistic insights into processes essential for ensuring error-free chromosome segregation.
- Open to
- Public
- Phone
- (607) 216-2439
- Sponsor
-
yiming niu
(607) 216-2439
yniu@rockefeller.edu