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Event Detail (Archived)

Tissue Architecture Mechanisms of Cancer Prevention

Cancer Biology and Genetics

  • This event already took place in February 2025
  • 116 Rockefeller Research Laboratories, MSKCC, 430 E. 67th St.

Event Details

Type
Other Tri-Institutional Events
Speaker(s)
Hendrik Messal, Ph.D., postdoctoral researcher, The Netherlands Cancer Institute
Speaker bio(s)

Dr. Messal's research explores the role of tissue architecture in early tumor suppression and initiation. By leveraging human organ tissue-clearing and long-term intravital microscopy technologies, Dr. Messal investigates the interactions between mutant cells and their surrounding tissue environment, aiming to identify key bottlenecks in tumor progression. His findings reveal that intact tissue compartmentalization restricts mutant cell expansion, preventing tumor initiation, while disruptions caused by tissue damage or physiological remodeling erode these defenses, enabling lesion formation. Dr. Messal will present insights into the molecular and cellular mechanisms underlying these processes, including the influence of epithelial geometry on clonal transformation.

Open to
Public
Host
Scott Lowe
Reception
Refreshments, 10:45 a.m.
Phone
(646) 888-3714
Sponsor
Niesha Hunte
(646) 888-3713
hunten@mskcc.org


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