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Event Detail (Archived)

Optical Electrophysiology for Dissecting Cortical Microcircuits

  • February 18, 2020
  • 4:00 PM - 5:00 PM
  • A Level Physics Seminar Room, Room A30, Smith Hall Annex (CRC)

Event Details

Center for Studies in Physics and Biology Seminars
Adam Cohen, Ph.D., professor, Harvard University

Melanie Lee
(212) 327-8636
Open to
Melanie Lee
(212) 327-8636
Combined optogenetic perturbation and voltage imaging enables high-resolution mapping of bioelectrical dynamics in intact tissues. I will describe application to Layer 1 of the mouse barrel cortex. We developed techniques to distinguish the separate contributions of excitatory and inhibitory synaptic inputs to membrane potential. Using these tools, we deciphered how the sensory-evoked responses emerged from local network dynamics.

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