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Upcoming Event

Optical Microscopy with Wavefront Control for Neuroscience

  • September 17, 2019
  • 4:00 PM - 5:00 PM
  • A Level Physics Seminar Room, Room A30, Smith Hall Annex (CRC)

Event Details

Center for Studies in Physics and Biology Seminars
Raphael Turcotte, Ph.D., Postdoctoral Research Assistant, University of Oxford

Optical microscopy has become an essential tool for neuroscientists. The primary reason for this success is that light enables the interrogation of living tissue in its physiological context at the length-scale of neurons and their subcellular components. Nevertheless, the quality of optical images is depth-dependent, because biological samples induce aberrations and scatter light, which ultimately limits imaging depth. In this talk,  Turcotte will discuss how wavefront control (WC), an approach enabling the sculpting of light, can alleviate these issues for brain imaging in live animals for several imaging modalities. First, Turcotte will show that WC can be implemented for two-photon fluorescence imaging to improve the quality of structural imaging and the accuracy of functional measurements. Then, Turcotte will illustrate how WC is essential for achieving super-resolution imaging (structured illumination microscopy) in the living brain. Finally, Turcotte will examine how WC plays an essential role in minimally invasive micro-endoscopy with multimode optical fibers and thus enables subcellular imaging centimeters into the brain in vivo.

Melanie Lee
(212) 327-8636
Open to
Melanie Lee
(212) 327-8636

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