Jordan Orange, M.D., Ph.D., Chair of Pediatrics, Columbia University, "Learning about NK cells through inborn errors of immunity.”
Dr. Orange's research has focused on the fundamental cell biology of intercellular immune interactions, novel causes of immune diseases as well as mechanistic insights gained from primary immunodeficiency. He has participated in gene discovery efforts and has contributed to the identification and understanding of a number novel genetic immune diseases – including most recently “Copa Syndrome”, which was recognized with the Lee Howley Sr. Prize from the Arthritis Foundation. Dr. Orange's work has also benefited from insights gained from the biology of primary immunodeficiency and has succeeded in translating back to patients through an ongoing phase-I clinical trial and related efforts. Dr. Orange's laboratory has been recognized for innovation in high- and super-resolution imaging of human immune cells and applying advanced cell biological technologies to human immunodeficiency. He is the recipient of the 2017 E. Mead Johnson Award, given by the Society for Pediatric Research, honoring his clinical and research achievements in pediatrics. The American Pediatric Society recognized Dr. Orange in 2015, awarding him the Norman J. Siegel New Member Outstanding Science Award and in 2009 he received the Justin Daland Prize from the American Philosophical Society for work in defining human natural killer cell deficiencies and Excellence in Patient-Oriented Clinical Investigation. Dr. Orange has trained and mentored more than 30 predoctoral, postdoctoral and graduate students over the past 10 years. Dr. Orange's work has been continuously funded by the National Institutes of Health, and he has and published over 200 manuscripts.