Chemical Dissection of Host-Microbe Interactions
- Friday Lecture Series
Howard C. Hang, Ph.D., Richard E. Salomon Family Associate Professor and head, Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University
The Hang laboratory is broadly interested in the molecular mechanisms by which chemical signals modulate host-microbe interactions in physiology and disease. These chemical signals (metabolites) may be derived from host metabolism or the environment (diet or microbiota) and significantly affect host susceptibility to infection. To dissect the chemical mechanisms that govern host-microbe interactions, the Hang laboratory has developed innovative methods to characterize metabolite-protein modifications and discovered unpredicted functions in cell biology, host immunity, and pathogen virulence. As the microbiota and their associated metabolites have emerged as major factors in modulating pathogen infection, they have employed key animal models to discover novel protective factors from specific microbiota species and utilized chemical methods to characterize microbiota metabolite targets and their mechanisms of action in host cells and pathogens. These studies have revealed evolutionarily conserved mechanisms of host-microbe interactions and afforded new leads for therapeutic development.
Hang received his undergraduate degree from the University of California, Santa Cruz, and his Ph.D. from the University of California, Berkeley. Before joining Rockefeller, he studied innate and adaptive immunity as a Damon Runyon Cancer Research Foundation Fellow at Harvard Medical School and at the Whitehead Institute for Biomedical Research. Hang is a recipient of the Irma T. Hirschl/Monique Weill-Caulier Trust Research Award, the Ellison Medical Foundation New Scholar Award, and an Eli Lilly Award in Biological Chemistry.
- Open to
- Tarun Kapoor
- Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
- Justin Sloboda
- (212) 327-7785