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Understanding Cortical Development and Disease: From Embryos to Brain Organoids

Event Details

Friday Lecture Series
Paola Arlotta, Ph.D., associate member, Stanley Center for Psychiatric Research, Broad Institute; chair, department of stem cell and regenerative biology, Golub Family Professor of Stem Cell and Regenerative Biology, Harvard University

Much remains unknown regarding the cellular and molecular mechanisms governing mammalian brain development. Focusing on the cerebral cortex, this lecture will present data on the mechanistic principles that control the developmental generation of cellular diversity in vivo and consider to what extent processes of cortical development can be replicated outside the embryo, within brain organoids. This lecture will also discuss the challenges of modeling human corticogenesis in the dish and the promise that brain organoids hold to investigate complex human neurodevelopmental disease.

Paola Arlotta's work aims at understanding the molecular laws that govern the birth, differentiation, and assembly into working circuitry of neuronal diversity in the cerebral cortex. She strives to integrate developmental and evolutionary knowledge to inform novel strategies for circuit repair in the cortex and for modeling of neuropsychiatric disease in vitro using brain organoids. Arlotta received her M.S. in biochemistry from the University of Trieste, Italy and her Ph.D. in molecular biology from the University of Portsmouth, UK. She subsequently completed her postdoctoral training in neuroscience at Harvard Medical School.  Arlotta is the recipient of many awards, including the 2017 George Ledlie Prize from Harvard, The Fannie Cox Prize for excellence in science teaching, the 2018 Friedrich Wilhelm Bessel Research Award from the Humboldt Foundation, and a 2019 Harvard College Professorship.

Justin Sloboda
(212) 327-7785
Open to
Ali Brivanlou
Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
Justin Sloboda
(212) 327-7785

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