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Event Detail (Archived)

Targeting RNA for Degradation by the Eukaryotic RNA Exosome

Event Details

Friday Lecture Series
Christopher D. Lima, Ph.D., professor, Structural Biology Program, member, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center; investigator, Howard Hughes Medical Institute

RNA degradation and quality control is a critical process that ensures that unwanted or damaged RNA is cleared from cells while preserving the integrity of other RNA species. The RNA exosome is responsible for the majority of processes involving 3' to 5' nuclear RNA processing or decay. The exosome includes a non-catalytic nine subunit core, at least two associated ribonucleases, Rrp44 (aka Dis3) and Rrp6, that interact with several other co-factors that link the RNA exosome to processing complexes that prepare, present, or unwind RNA substrates for degradation. Dr. Lima will present results from ongoing biochemical and structural studies aimed at understanding how RNA exosome co-factors coordinate the activities of the RNA exosome in processes that are central to RNA homeostasis.

Dr. Lima received his Ph.D. in 1994 from Northwestern University in Dr. Mondragon’s lab. His postdoctoral studies as a Helen Hay Whitney Fellow were conducted in Dr. Hendrickson’s lab at Columbia University. In October of 1998, he joined the faculty at Weill Cornell Medicine. He moved his laboratory to the Sloan Kettering Institute in 2003, where he studies pathways that contribute to RNA processing and post-translational modification by ubiquitin-like proteins. His awards include a Beckman Young Investigator Award, a Rita Allen Scholarship, and a Louise and Allston Boyer Young Investigator Award. He was elected to the American Academy of Arts and Sciences in 2017.

Justin Sloboda
(212) 327-7785
Open to
Sebastian Klinge, Ph.D.
Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
Justin Sloboda
(212) 327-7785

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