Biochemistry & Cell Biology

RU 380: Muir, et al. Generation of Semi-Synthetic Polypeptides.

RU 383: Dean, et al. Novel tumor suppressors: the human G2 checkpoint genes.
This invention describes the DNA sequences of mammalian, including human single strand gap response (SSGR) proteins involved in activation of a DNA repair/cell cycle checkpoint pathway, and their diagnostic and therapeutic applications. Transgenic mice that lack functional copies of the genes and are characterized by spontaneous tumor development, are also described.

RU 431: Darnell J, et al. A New Family of Transcription Factors Involved in Oncogenesis.

RU 642: MacKinnon, et al. A Novel Target for Modulating Ion Channel Function: The Voltage-Sensing Domain.

RU 648, 864, 927: Darnell, et al. A Novel Method for Identification of Targets for RNA-Binding Proteins.

RU 648, 864, 927, 902: Darnell, et al. CLIP and HITS-CLIP: Novel Techniques to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes.

RU 665: Allis, et al. Binary Switches in Gene Expression: The Histone Code.

RU 681, 697, 732, 749: Tuschl, et al. Human and Viral MicroRNA Molecules and Inhibition of Their RNA Interference (RNAi) Activity .

RU 870: Sakmar, et al. A Novel Method for the Production of Nanoscale Membrane Particles.

RU 902: Tuschl, et al. A Novel Technique to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes.

RU 910, 1030: Tuschl, et al. A Novel Method For MicroRNA, Non-coding RNA and mRNA Detection By In-situ Hybridization.

RU 942: MacKinnon, et al. A Novel Target for Modulating the Kir Potassium Ion Channel: The Turret Domain.