Biochemistry & Cell Biology
RU 380: Muir, et al. Generation of Semi-Synthetic Polypeptides.
RU 383: Dean, et al. Novel tumor suppressors: the human G2 checkpoint genes.
This invention describes the DNA sequences of mammalian, including human single strand gap response (SSGR) proteins involved in activation of a DNA repair/cell cycle checkpoint pathway, and their diagnostic and therapeutic applications. Transgenic mice that lack functional copies of the genes and are characterized by spontaneous tumor development, are also described.
RU 396, 642: McKinnon, et al. Use of Ion Channel Components to Screen for Modulators of Ion Channel Function.
RU 431: Darnell J, et al. A New Family of Transcription Factors Involved in Oncogenesis.
RU 648, 864, 927: Darnell, et al. A Novel Method for Identification of Targets for RNA-Binding Proteins.
RU 681, 697, 732, 749: Tuschl, et al. Human and viral microRNA molecules and inhibition of their RNAi activity.
RU 870: Sakmar, et al. A Novel Method for the Production of Nanoscale Membrane Particles.
RU 902: Tuschl, et al. A Novel Technique to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes.
RU 910: Tuschl, et al. A Novel Method For MicroRNA Detection By In-Situ Hybridization.
