RU 367: Burley et al. US patent numbers: 5,872,011 and 6,020,162: Crystal of a protein-ligand complex containing an N-terminal truncated EIF4E, and methods of use thereof.
The crystal structure of an N-terminal truncated elongation factor, eIF4E ligand complex and methods of identifying antagonists of the eIF4E protein, which can be used to regulate protein synthesis in cells are described.

RU 374: Darnell et al. US patent numbers: 6,087,478 and 6,312,887 B1: Crystal of the N-terminal domain of a STAT protein and methods of use thereof.
This invention describes the three dimensional structure of the N-terminal domain of a STAT protein and methods for using the information in drug discovery and development.

RU 408: Chen et al. US patent number: 6,160,092: Crystal of the core portion of a signal transducer and activator of transcription (STAT).
This invention describes the three dimensional structure of the core portion of the STAT protein in dimeric form with an 18-mer duplex DNA that contains a binding site for the STAT-dimer. Methods for using the information in drug discovery and development are also described.

RU 407: Kuriyan et al. US patent numbers: 6,156,526 and 6,117,663: Crystal of a Ras-Sos complex and methods of use thereof.
Interaction between Ras-Sos plays key role in the regulation of cell propagation & differentiation, the structural data obtained for these complex can be used for the rational design of drugs that modulate cell proliferation.

RU 733 (Rice): Novel structural targets in the NS5A protein of Hepatitis C virus.

RU 745 (Rice): NStructural Targets in the NS2 Protease of Hepatitis C Virus