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RU 380-453: Muir, et al; U.S. patent number 6,875,594: Generation of semi-synthetic polypeptides.
RU 383: Dean, et al. US patent number: 6,455,681 B1: Novel tumor suppressors: the human G2 checkpoint genes (O'Donnell).
This invention describes the DNA sequences of mammalian, including human single strand gap response (SSGR) proteins involved in activation of a DNA repair/cell cycle checkpoint pathway, and their diagnostic and therapeutic applications. Transgenic mice that lack functional copies of the genes and are characterized by spontaneous tumor development, are also described.
RU 386: Brivanlou, et al. US patents: 5,952,213 and 6,291,651 B1: Novel Src kinase for drug development.
The patents describe a unique src-family kinase (SFK), laloo that plays a key role in the transformation of early stage embryonic cells to mesodermal cells. The nucleic acid and amino acid sequences are disclosed as well as antibodies to the kinase.
RU 392: Brivanlou, et al. US patent number: 6,337,392: A novel and tissue-specific lens transcriptional control element
The patent describes lens transcriptional control elements including the mouse Pax-6 gene 5 flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This element provides an important tool in transgenic analyses of lens formation and allows for the identification of transcription factors with a central function in lens development.
RU 396-642: McKinnon, et al. Use of Ion Channel Components to Screen for Modulators of Ion Channel Function
RU 430-431:Darnell J, et al. A New Family of Transcription Factors Involved in Oncogenesis
RU 455: Roeder, et al. Cost-effective system for high-level expression of recombinant proteins.
RU 630: Rambukkana, et al. Non-nuclear transfer reprogramming of adult differentiated cells to multipotent stem cell-like cells.
RU 648, 864, 927: Darnell R., et al. A Novel Method for Identification of Targets for RNA-Binding Proteins.
RU 723: Brivanlou, et al. Identification Of Novel Factors That Induce Insulin Expression In Embryonic Cells.
RU 681, 697, 732, 749: Tuschl, et al. Human and viral microRNA molecules and inhibition of their RNAi activity.
RU 799: Kapoor, et al.Novel Chemical Inhibitors of Histone Methyltransferases.
RU 870: T. Sakmar, T. Huber, S. Banerjee, et al.A Novel Method for the Production of Nanoscale Membrane Particles
RU 899: Libchaber A., and Salman H., et. al. Soluble Oxygen Detector for In Vivo Applications
RU 902: Tuschl T., et al.A Novel Technique to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes
RU 908: Hang H., et al. Novel Chemical Tools for the Detection of Lipidated Proteins
RU 910: Tuschl T., and Pena J., et al. A Novel Method For MicroRNA Detection By In-Situ Hybridization
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