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The Structural Biology Resource Center (SBRC) is home to state-of-the-art X-ray equipment for the determination of the three-dimensional structures of biological macromolecules. The Center houses two generators equipped with sub-freezing sample apparatus and four detectors: (1) The Rigaku/MSC RUH2R dual port generator with cryo-crystallography equipment and two detectors: RaxisIV and Raxis IV++ (located in RRB 130); and (2) The Rigaku/MSC microMax 007HF generator (located in RRB 327). The latter is equipped with Varimax optics that can be adjusted for small samples (300 micron), X-stream cryosystems and two RaxisIV++ detectors.
This recently acquired HighFlux HomeLabTM is exceptional for small samples and complex structures and has already proven to be an invaluable resource for evaluating and refining macromolecular crystals while providing the highest quality in-house data.
The Center provides training and expert guidance for researchers undertaking crystallographic structure determination. The Center is also the liaison between the University and Brookhaven National Labs NSLS synchrotron X-ray PRT beam lines.
The SBRC offers:
- maintenance of the instruments
- assistance with experimental design
- advise on data collection strategies
- individualized instruction and training on the instruments
- consultation on data analysis
- experimental troubleshooting
The mission of the SBRC is to offer the most productive structural biology facility through high quality, reliability and open dialog to the benefit of research at Rockefeller University.
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