Investigator, Howard Hughes Medical Institute
Program in Immunology
Dr. Rudensky’s research is focused on understanding how T cells develop and their role in immunity and tolerance. Major areas of interest in his laboratory include the molecular and cellular mechanisms governing the differentiation and function of CD4 T lymphocytes; the roles these cells play in controlling autoimmunity, tumor immunity, and immunity to infections; and the maintenance of immune homeostasis
at environmental interfaces.
Dr. Rudensky is particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; in the plasticity of regulatory T cell transcriptional and functional programs; and in the molecular mechanisms of regulatory T cell lineage stability. In these studies, the Rudensky laboratory employs a wide range of experimental techniques, including traditional biochemical and molecular biological analyses; genetic approaches including conventional and conditional gene targeting and transgenesis; mass spectrometry; large-scale gene expression analyses and bioinformatics; and classical immunological analyses utilizing both cellular in vitro techniques and whole animal experimentation.
Feng, Y. et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell 158, 749–763 (2014).
Arpaia, N. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451–455 (2013).
Samstein, R.M. et al. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 151, 153–166 (2012).