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Chemical and Structural Biology

Chemical and structural biologists at Rockefeller work to identify and characterize molecules and molecular assemblies involved in key biological processes. They employ a full range of modern tools, including x-ray crystallography, magnetic resonance  spectroscopy, electron microscopy, mass spectrometry, bioinformatics, computer modeling and simulation and chemical synthesis, as well as the techniques of molecular biology and genetics. Driven by advances in genetic sequencing, their work to relate  one-dimensional DNA sequences to the three-dimensional protein architectures they encode represents significant progress in the quest to understand the complex chemical and physical transformations that underlie living systems.