How a cellular pore opens and closes
It turns out that the cystic fibrosis chloride channel, which allows salts in and out of cells throughout the body, is structured like a peanut butter sandwich
For 10 years, David Gadsby has
been essentially blindfolded as he tried to open a cellular door
secured by both key and combination locks.
Recently, he succeeded in unlocking the door,
and revealed the workings of the cystic fibrosis chloride channel,
one of the specialized openings in the membrane of cells and the
protein that is defective in people with cystic fibrosis.
December 12, 2003
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